Frequent <i>RNF43</i> mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma

Yaqi Li; Jian Li; Renjie Wang; Long Zhang; Guoxiang Fu; Xueying Wang; Yebin Wang; Chuantao Fang; Dandan Zhang; Duo Du; Xiaoji Ma; Mengxue Pan; Qiang Guo; Xiaoya Xu; Xiang Hu; Yi Zhou; Shaobo Mo; Huijun Wang; Jianjun Gao; Shenglin Huang; Yun Liu; Sanjun Cai; Guoqiang Hua; Junjie Peng; Fa-Xing Yu

doi:10.1007/s13238-020-00691-0

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Protein Cell ›› 2020, Vol. 11 ›› Issue (4) : 292-298. DOI: 10.1007/s13238-020-00691-0

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Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma

Yaqi Li¹^,² ,
Jian Li³^,⁴ ,
Renjie Wang¹^,² ,
Long Zhang¹^,²^,⁵ ,
Guoxiang Fu⁶ ,
Xueying Wang³^,⁴ ,
Yebin Wang³^,⁴ ,
Chuantao Fang³^,⁴ ,
Dandan Zhang⁷ ,
Duo Du⁷ ,
Xiaoji Ma¹^,² ,
Mengxue Pan⁶ ,
Qiang Guo⁶ ,
Xiaoya Xu⁶ ,
Xiang Hu¹^,² ,
Yi Zhou⁶ ,
Shaobo Mo¹^,² ,
Huijun Wang³ ,
Jianjun Gao⁶ ,
Shenglin Huang⁸ ,
Yun Liu⁷ ,
Sanjun Cai¹^,² ,
Guoqiang Hua⁹ ,
Junjie Peng¹^,² ,
Fa-Xing Yu³^,⁴

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Yaqi Li, Jian Li, Renjie Wang, Long Zhang, Guoxiang Fu, Xueying Wang, Yebin Wang, Chuantao Fang, Dandan Zhang, Duo Du, Xiaoji Ma, Mengxue Pan, Qiang Guo, Xiaoya Xu, Xiang Hu, Yi Zhou, Shaobo Mo, Huijun Wang, Jianjun Gao, Shenglin Huang, Yun Liu, Sanjun Cai, Guoqiang Hua, Junjie Peng, Fa-Xing Yu. Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma. Protein Cell, 2020, 11(4): 292‒298 https://doi.org/10.1007/s13238-020-00691-0

References

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[1]	Anjomshoaa A, Nasri S, Humar B, McCall JL, Chatterjee A, Yoon HS, McNoe L, Black MA, Reeve AE (2009) Slow proliferation as a biological feature of colorectal cancer metastasis. Br J Cancer 101:822–828 CrossRef Google scholar

[2]	Borger ME, Gosens MJ, Jeuken JW, van Kempen LC, van de Velde CJ, van Krieken JH, Nagtegaal ID (2007) Signet ring cell differentiation in mucinous colorectal carcinoma. J Pathol 212:278–286 CrossRef Google scholar

[3]	Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61:759–767 CrossRef Google scholar

[4]	Giannakis M, Hodis E, Mu XJ, Yamauchi M, Rosenbluh J, Cibulskis K, Saksena G, Lawrence MS, Qian ZR, Nishihara R(2014) RNF43 is frequently mutated in colorectal and endometrial cancers. Nat Genet 46:1264–1266 CrossRef Google scholar

[5]	Hugen N, van de Velde CJ, de Wilt JH, Nagtegaal ID (2014) Metastatic pattern in colorectal cancer is strongly influenced by histological subtype. Ann Oncol 25:651–657 CrossRef Google scholar

[6]	Inamura K, Yamauchi M, Nishihara R, Kim SA, Mima K, Sukawa Y, Li T, Yasunari M, Zhang X, Wu K (2015) Prognostic significance and molecular features of signet-ring cell and mucinous components in colorectal carcinoma. Ann Surg Oncol 22:1226–1235 CrossRef Google scholar

[7]	Kang H, O’Connell JB, Maggard MA, Sack J, Ko CY (2005) A 10-year outcomes evaluation of mucinous and signet-ring cell carcinoma of the colon and rectum. Dis Colon Rectum 48:1161–1168 CrossRef Google scholar

[8]	Korphaisarn K, Morris V, Davis JS, Overman MJ, Fogelman DR, Kee BK, Dasari A, Raghav KPS, Shureiqi I, Trupti M (2019) Signet ring cell colorectal cancer: genomic insights into a rare subpopulation of colorectal adenocarcinoma. Br J Cancer 121:505–510 CrossRef Google scholar

[9]	Nam JY, Oh BY, Hong HK, Bae JS, Kim TW, Ha SY, Park D, Lee WY, Kim HC, Yun SH (2018) Molecular characterization of colorectal signet-ring cell carcinoma using whole-exome and RNA sequencing. Transl Oncol 11:836–844 CrossRef Google scholar

[10]

Nitsche U, Zimmermann A, Spath C, Muller T, Maak M, Schuster T, Slotta-Huspenina J, Kaser SA, Michalski CW, Janssen KP (2013) Mucinous and signet-ring cell colorectal cancers differ from classical adenocarcinomas in tumor biology and prognosis. Ann Surg 258:775–782; discussion 782–773.

CrossRef Google scholar

[11]	Nusse R, Clevers H (2017) Wnt/beta-catenin signaling, disease, and emerging therapeutic modalities. Cell 169:985–999 CrossRef Google scholar

[12]	Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, Dimitriadoy S, Liu DL, Kantheti HS, Saghafinia S (2018) Oncogenic signaling pathways in the cancer genome atlas. Cell 173:321–337.e310 CrossRef Google scholar

[13]	Sung CO, Seo JW, Kim KM, Do IG, Kim SW, Park CK (2008) Clinical significance of signet-ring cells in colorectal mucinous adenocarcinoma. Mod Pathol 21:1533–1541 CrossRef Google scholar

[14]	TCGA (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487:330–337 CrossRef Google scholar

[15]	Yan HHN, Lai JCW, Ho SL, Leung WK, Law WL, Lee JFY, Chan AKW, Tsui WY, Chan ASY, Lee BCH (2017) RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut 66:1645–1656 CrossRef Google scholar