FBXW7 E3 ubiquitin ligase: degrading, not degrading, or being degraded

References

[1] Ikeda F, Dikic I (2008) Atypical ubiquitin chains: new molecular signals—protein modifications: beyond the usual suspects review series . Embo Rep 9(6):536–542

[2] Kirisako T, Kamei K, Murata S, Kato M, Fukumoto H, Kanie M, Sano S, Tokunaga F, Tanaka K, Iwai K (2006) A ubiquitin ligase complex assembles linear polyubiquitin chains . EMBO J 25 (20):4877–4887

[3] Lan H, Tan M, Zhang Q, Yang F, Wang S, Li H, Xiong X, Sun Y (2019) LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its demethylase activity . Proc Natl Acad Sci USA 116(25):12311–12320

[4] Li Y, Hu K, Xiao X, Wu W, Yan H, Chen H, Chen Z, Yin D (2018) FBW7 suppresses cell proliferation and G2/M cell cycle transition via promoting γ-catenin K63-linked ubiquitylation . Biochem Biophys Res Commun 497(2):473–479

[5] Mao JH, Perez-losada J, Wu D, Delrosario R, Tsunematsu R, Nakayama KI, Brown K, Bryson S, Balmain A (2004) Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene . Nature 432(7018):775–779

[6] Nakayama KI, Nakayama K (2006) Ubiquitin ligases: cell-cycle control and cancer . Nat Rev Cancer 6(5):369–381

[7] Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 . Cell 119(7):941–953

[8] VanDemark AP, Hofmann RM, Tsui C, Pickart CM, Wolberger C (2001) Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer . Cell 105 (6):711–720

[9] Wang Z, Liu P, Inuzuka H, Wei W (2014) Roles of F-box proteins in cancer . Nat Rev Cancer 14(4):233–247

[10] Welcker M, Clurman BE (2008) FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation . Nat Rev Cancer 8(2):83–93

[11] Zhang Q, Karnak D, Tan M, Lawrence TS, Morgan MA, Sun Y (2016) FBXW7 facilitates nonhomologous end-Joining via K63-linked polyubiquitylation of XRCC4 . Mol Cell 61(3):419–433

[12] Zhou W, Wei W, Sun Y (2013) Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases . Cell Res 23(5):599–619

RIGHTS & PERMISSIONS

The Author(s) 2019