FBXW7 E3 ubiquitin ligase: degrading, not degrading, or being degraded

Huiyin Lan; Yi Sun

doi:10.1007/s13238-019-0652-x

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Protein Cell ›› 2019, Vol. 10 ›› Issue (12) : 861-863. DOI: 10.1007/s13238-019-0652-x

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FBXW7 E3 ubiquitin ligase: degrading, not degrading, or being degraded

Huiyin Lan¹^,² ,
Yi Sun¹^,³

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Huiyin Lan, Yi Sun. FBXW7 E3 ubiquitin ligase: degrading, not degrading, or being degraded. Protein Cell, 2019, 10(12): 861‒863 https://doi.org/10.1007/s13238-019-0652-x

References

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[1]	Ikeda F, Dikic I (2008) Atypical ubiquitin chains: new molecular signals—protein modifications: beyond the usual suspects review series . Embo Rep 9(6):536–542 CrossRef Google scholar

[2]	Kirisako T, Kamei K, Murata S, Kato M, Fukumoto H, Kanie M, Sano S, Tokunaga F, Tanaka K, Iwai K (2006) A ubiquitin ligase complex assembles linear polyubiquitin chains . EMBO J 25 (20):4877–4887 CrossRef Google scholar

[3]	Lan H, Tan M, Zhang Q, Yang F, Wang S, Li H, Xiong X, Sun Y (2019) LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its demethylase activity . Proc Natl Acad Sci USA 116(25):12311–12320 CrossRef Google scholar

[4]	Li Y, Hu K, Xiao X, Wu W, Yan H, Chen H, Chen Z, Yin D (2018) FBW7 suppresses cell proliferation and G2/M cell cycle transition via promoting γ-catenin K63-linked ubiquitylation . Biochem Biophys Res Commun 497(2):473–479 CrossRef Google scholar

[5]	Mao JH, Perez-losada J, Wu D, Delrosario R, Tsunematsu R, Nakayama KI, Brown K, Bryson S, Balmain A (2004) Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene . Nature 432(7018):775–779 CrossRef Google scholar

[6]	Nakayama KI, Nakayama K (2006) Ubiquitin ligases: cell-cycle control and cancer . Nat Rev Cancer 6(5):369–381 CrossRef Google scholar

[7]	Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 . Cell 119(7):941–953 CrossRef Google scholar

[8]	VanDemark AP, Hofmann RM, Tsui C, Pickart CM, Wolberger C (2001) Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer . Cell 105 (6):711–720 CrossRef Google scholar

[9]	Wang Z, Liu P, Inuzuka H, Wei W (2014) Roles of F-box proteins in cancer . Nat Rev Cancer 14(4):233–247 CrossRef Google scholar

[10]	Welcker M, Clurman BE (2008) FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation . Nat Rev Cancer 8(2):83–93 CrossRef Google scholar

[11]	Zhang Q, Karnak D, Tan M, Lawrence TS, Morgan MA, Sun Y (2016) FBXW7 facilitates nonhomologous end-Joining via K63-linked polyubiquitylation of XRCC4 . Mol Cell 61(3):419–433 CrossRef Google scholar

[12]	Zhou W, Wei W, Sun Y (2013) Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases . Cell Res 23(5):599–619 CrossRef Google scholar