Low-dose quercetin positively regulates mouse healthspan

Lingling Geng, Zunpeng Liu, Si Wang, Shuhui Sun, Shuai Ma, Xiaoqian Liu, Piu Chan, Liang Sun, Moshi Song, Weiqi Zhang, Guang-Hui Liu, Jing Qu

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Protein Cell ›› 2019, Vol. 10 ›› Issue (10) : 770-775. DOI: 10.1007/s13238-019-0646-8
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Low-dose quercetin positively regulates mouse healthspan

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Lingling Geng, Zunpeng Liu, Si Wang, Shuhui Sun, Shuai Ma, Xiaoqian Liu, Piu Chan, Liang Sun, Moshi Song, Weiqi Zhang, Guang-Hui Liu, Jing Qu. Low-dose quercetin positively regulates mouse healthspan. Protein Cell, 2019, 10(10): 770‒775 https://doi.org/10.1007/s13238-019-0646-8

References

[1]
Bitto A, Ito TK, Pineda VV, LeTexier NJ, Huang HZ, Sutlief E, Tung H, Vizzini N, Chen B, Smith K (2016) Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. eLife 5:e16351
CrossRef Google scholar
[2]
De Cecco M, Criscione SW, Peterson AL, Neretti N, Sedivy JM, Kreiling JA (2013) Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues. Aging 5:867–883
CrossRef Google scholar
[3]
De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD (2019) L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature 566:73–78
CrossRef Google scholar
[4]
Geng L, Liu Z, Zhang W, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Sun L (2018) Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein Cell 10(6):417–435
CrossRef Google scholar
[5]
He X, Song M, Qu J, Guo Y, Cao H, Sun R, Liu G-H, Shen Y, Major Program Expert G (2019) Basic and translational aging research in China: present and future. Protein Cell. https://doi.org/10.1007/s13238-019-0617-0
CrossRef Google scholar
[6]
Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ (2013) Metformin improves healthspan and lifespan in mice. Nat Commun 4:2192
CrossRef Google scholar
[7]
Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A (2018) Nicotinamide improves aspects of healthspan, but not lifespan, in mice. Cell Metab 27:667–676.e664
CrossRef Google scholar
[8]
Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM (2017) Cellular senescence drives age-dependent hepatic steatosis. Nat Commun 8:15691–15691
CrossRef Google scholar
[9]
Ono K, Nakane H, Fukushima M, Chermann J-C, BarrÉ-Sinoussi F (1990) Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. Eur J Biochem 190:469–476
CrossRef Google scholar
[10]
Shoskes DA, Zeitlin SI, Shahed A, Rajfer J (1999) Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology 54:960–963
CrossRef Google scholar
[11]
Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL (2019) LINE1 derepression in aged wild-type and SIRT6-deficient mice drives inflammation. Cell Metab 29:871–885.e875
CrossRef Google scholar
[12]
Takahashi A, Loo TM, Okada R, Kamachi F, Watanabe Y, Wakita M, Watanabe S, Kawamoto S, Miyata K, Barber GN (2018) Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells. Nat Commun 9:1249
CrossRef Google scholar
[13]
Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG(2018) Senolytics improve physical function and increase lifespan in old age. Nat Med 24:1246–1256
CrossRef Google scholar
[14]
Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A (2015) A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science (New York, NY) 348:1160–1163
CrossRef Google scholar
[15]
Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M (2015) The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 14:644–658
CrossRef Google scholar

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