Low-dose quercetin positively regulates mouse healthspan

Lingling Geng , Zunpeng Liu , Si Wang , Shuhui Sun , Shuai Ma , Xiaoqian Liu , Piu Chan , Liang Sun , Moshi Song , Weiqi Zhang , Guang-Hui Liu , Jing Qu

Protein Cell ›› 2019, Vol. 10 ›› Issue (10) : 770 -775.

PDF (1447KB)
Protein Cell ›› 2019, Vol. 10 ›› Issue (10) : 770 -775. DOI: 10.1007/s13238-019-0646-8
LETTER
LETTER

Low-dose quercetin positively regulates mouse healthspan

Author information +
History +
PDF (1447KB)

Cite this article

Download citation ▾
Lingling Geng, Zunpeng Liu, Si Wang, Shuhui Sun, Shuai Ma, Xiaoqian Liu, Piu Chan, Liang Sun, Moshi Song, Weiqi Zhang, Guang-Hui Liu, Jing Qu. Low-dose quercetin positively regulates mouse healthspan. Protein Cell, 2019, 10(10): 770-775 DOI:10.1007/s13238-019-0646-8

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Bitto A, Ito TK, Pineda VV, LeTexier NJ, Huang HZ, Sutlief E, Tung H, Vizzini N, Chen B, Smith K (2016) Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. eLife 5:e16351

[2]

De Cecco M, Criscione SW, Peterson AL, Neretti N, Sedivy JM, Kreiling JA (2013) Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues. Aging 5:867–883

[3]

De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD (2019) L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature 566:73–78

[4]

Geng L, Liu Z, Zhang W, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Sun L (2018) Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein Cell 10(6):417–435

[5]

He X, Song M, Qu J, Guo Y, Cao H, Sun R, Liu G-H, Shen Y, Major Program Expert G (2019) Basic and translational aging research in China: present and future. Protein Cell.

[6]

Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ (2013) Metformin improves healthspan and lifespan in mice. Nat Commun 4:2192

[7]

Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A (2018) Nicotinamide improves aspects of healthspan, but not lifespan, in mice. Cell Metab 27:667–676.e664

[8]

Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM (2017) Cellular senescence drives age-dependent hepatic steatosis. Nat Commun 8:15691–15691

[9]

Ono K, Nakane H, Fukushima M, Chermann J-C, BarrÉ-Sinoussi F (1990) Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. Eur J Biochem 190:469–476

[10]

Shoskes DA, Zeitlin SI, Shahed A, Rajfer J (1999) Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology 54:960–963

[11]

Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL (2019) LINE1 derepression in aged wild-type and SIRT6-deficient mice drives inflammation. Cell Metab 29:871–885.e875

[12]

Takahashi A, Loo TM, Okada R, Kamachi F, Watanabe Y, Wakita M, Watanabe S, Kawamoto S, Miyata K, Barber GN (2018) Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells. Nat Commun 9:1249

[13]

Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG(2018) Senolytics improve physical function and increase lifespan in old age. Nat Med 24:1246–1256

[14]

Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A (2015) A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science (New York, NY) 348:1160–1163

[15]

Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M (2015) The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 14:644–658

RIGHTS & PERMISSIONS

The Author(s) 2019

AI Summary AI Mindmap
PDF (1447KB)

Supplementary files

PAC-0770-19182-LGH_suppl_1

858

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/