Crystal structure and function of Rbj: A constitutively GTP-bound small G protein with an extra DnaJ domain

References

[1] Bos JL (1989) ras oncogenes in human cancer: a review. Cancer Res 49:4682–4689

[2] Chardin P (1999) Rnd proteins: a new family of Rho-related proteins that interfere with the assembly of filamentous actin structures and cell adhesion. Prog Mol Subcell Biol 22:39–50

[3] Chen T, Yang M, Yu Z, Tang S, Wang C, Zhu X, Guo J, Li N, Zhang W, Hou J (2014) Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 in tumor progression. Cancer Cell 25:682–696

[4] Elias M, Archibald JM (2009) The RJL family of small GTPases is an ancient eukaryotic invention probably functionally associated with the flagellar apparatus. Gene 442:63–72

[5] Fiegen D, Blumenstein L, Stege P, Vetter IR, Ahmadian MR (2002) Crystal structure of Rnd3/RhoE: functional implications. FEBS Lett 525:100–104

[6] Goitre L, Trapani E, Trabalzini L, Retta SF (2014) The Ras superfamily of small GTPases: the unlocked secrets. Methods Mol Biol 1120:1–18

[7] Karnoub AE, Weinberg RA (2008) Ras oncogenes: split personalities . Nat Rev Mol Cell Biol 9:517–531

[8] Karzai AW, McMacken R (1996) A bipartite signaling mechanism involved in DnaJ-mediated activation of the Escherichia coli DnaK protein. J Biol Chem 271:11236–11246

[9] Kityk R, Kopp J, Mayer MP (2018) Molecular mechanism of J-domain-triggered ATP hydrolysis by Hsp70 chaperones. Mol Cell 69:227–237

[10] Liu Q, Zhu H, Zhang C, Chen T, Cao X (2017) Small GTPase RBJ promotes cancer progression by mobilizing MDSCs via IL-6. Oncoimmunology 6:e1245265

[11] Nepomuceno-Silva JL, de Melo LD, Mendonca SM, Paixao JC, Lopes UG (2004) RJLs: a new family of Ras-related GTP-binding proteins. Gene 327:221–232

[12] Novelli ET, First JT, Webb LJ (2018) Quantitative measurement of intrinsic GTP hydrolysis for carcinogenic glutamine 61 mutants in H-Ras. Biochemistry 57:6356–6366

[13] Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM (2013) K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 503:548–551

[14] Scheidig AJ, Burmester C, Goody RS (1999) The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins. Structure 7:1311–1324

[15] Walsh P, Bursac D, Law YC, Cyr D, Lithgow T (2004) The J-protein family: modulating protein assembly, disassembly and translocation. EMBO Rep 5:567–571

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