Targeting oncogenic SOX2 in human cancer cells: therapeutic application

References

[1] Cui CP, Zhang Y, Wang C, Yuan F, Li H, Yao Y, Chen Y, Li C, Wei W, Liu CH (2018) Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation. Nat Commun 9:4648

[2] Feng R, Wen J (2015) Overviewof the rolesof Sox2in stem cell and development. Biol Chem 396:883–891

[3] Huser L, Novak D, Umansky V, Altevogt P, Utikal J (2018) Targeting SOX2 in anticancer therapy. Expert Opin Ther Targets 22:983–991

[4] Liu L, Liu C, Zhang Q, Shen J, Zhang H, Shan J, Duan G, Guo D, Chen X, Cheng J (2016) SIRT1-mediated transcriptional regulation of SOX2 is important for self-renewal of liver cancer stem cells. Hepatology 64:814–827

[5] Nakayama KI, Nakayama K (2006) Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer 6:369–381

[6] Novak D, Huser L, Elton JJ, Umansky V, Altevogt P, Utikal J (2019) SOX2 in development and cancer biology. Semin Cancer Biol. https://doi.org/10.1016/j.semcancer.2019.08.007

[7] Pietrobono S, Morandi A, Gagliardi S, Gerlini G, Borgognoni L, Chiarugi P, Arbiser JL, Stecca B (2016) Down-regulationof SOX2 underlies the inhibitory effects of the triphenylmethane gentian violet on melanoma cell self-renewal and survival. J Investig Dermatol 136:2059–2069

[8] Singh S, Trevino J, Bora-Singhal N, Coppola D, Haura E, Altiok S, Chellappan SP (2012) EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer. Mol Cancer 11:73

[9] Takahashi K, Yamanaka S (2006) Inductionof pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663–676

[10] Wu Q, Zhang L, Su P, Lei X, Liu X, Wang H, Lu L, Bai Y, Xiong T, Li D (2015) MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling. Cell Res 25:1314–1332

[11] Wuebben EL, Rizzino A (2017) The dark side of SOX2: cancer—a comprehensive overview. Oncotarget 8:44917–44943

[12] Yin Y, Xie CM, Li H, Tan M, Chen G, Schiff R, Xiong X, Sun Y (2019) The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells. Proc Natl Acad Sci USA 116:20528–20538

[13] Zhang C, Leng F, Saxena L, Hoang N, Yu J, Alejo S, Lee L,Qi D, Lu F, Sun H (2019) Proteolysis of methylated SOX2 protein is regulatedby L3MBTL3and CRL4(DCAF5) ubiquitin ligase. JBiol Chem 294:476–489

[14] Zhang X, Lu F, Wang J, Yin F, Xu Z, Qi D, Wu X, Cao Y, Liang W, Liu Y (2013) Pluripotent stem cell protein Sox2 confers sensitivity to LSD1 inhibition in cancer cells. Cell Rep 5:445–457

[15] Zhao Y, Morgan MA, Sun Y (2014) Targeting neddylation pathways to inactivate Cullin-RING ligases for anti-cancer therapy. Antioxid Redox Signal 21:2383–2400

[16] Zhou L, Zhang W, Sun Y, Jia L (2018) Protein neddylation and its alterations in human cancers for targeted therapy. Cell Signal 44:92–102

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2019 The Author(s)