Genetic evidence for asymmetric blocking of higher-order chromatin structure by CTCF/cohesin

Yujia Lu, Jia Shou, Zhilian Jia, Yonghu Wu, Jinhuan Li, Ya Guo, Qiang Wu

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Protein Cell ›› 2019, Vol. 10 ›› Issue (12) : 914-920. DOI: 10.1007/s13238-019-00656-y
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Genetic evidence for asymmetric blocking of higher-order chromatin structure by CTCF/cohesin

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Yujia Lu, Jia Shou, Zhilian Jia, Yonghu Wu, Jinhuan Li, Ya Guo, Qiang Wu. Genetic evidence for asymmetric blocking of higher-order chromatin structure by CTCF/cohesin. Protein Cell, 2019, 10(12): 914‒920 https://doi.org/10.1007/s13238-019-00656-y

References

[1]
Canzio D, Nwakeze CL, Horta A, Rajkumar SM, Coffey EL, Duffy EE, Duffie R, Monahan K, O’Keeffe S, Simon MD (2019) Antisense lncRNA transcription mediates DNA demethylation to drive stochastic protocadherin alpha promoter choice. Cell 177 (639–653):e615
CrossRef Google scholar
[2]
Guo Y, Monahan K, Wu H, Gertz J, Varley KE, Li W, Myers RM, Maniatis T, Wu Q (2012) CTCF/cohesin-mediated DNA looping is required for protocadherin alpha promoter choice. Proc Natl Acad Sci USA 109:21081–21086
CrossRef Google scholar
[3]
Guo Y, Xu Q, Canzio D, Shou J, Li J, Gorkin DU, Jung I, Wu H, Zhai Y, Tang Y (2015) CRISPR inversion of CTCF sites alters genome topology and enhancer/promoter function. Cell 162:900–910
CrossRef Google scholar
[4]
Huang HY, Wu Q (2016) CRISPR double cutting through the labyrinthine architecture of 3D genomes. J Genet Genomics 43:273–288
CrossRef Google scholar
[5]
Jain S, Ba Z, Zhang Y, Dai HQ, Alt FW (2018) CTCF-binding elements mediate accessibility of RAG substrates during chromatin scanning. Cell 174(102–116):e114
CrossRef Google scholar
[6]
Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB (2017) The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain. Nat Genet 49:1239–1250
CrossRef Google scholar
[7]
Monahan K, Rudnick ND, Kehayova PD, Pauli F, Newberry KM, Myers RM, Maniatis T (2012) Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of protocadherin-alpha gene expression. Proc Natl Acad Sci USA 109:9125–9130
CrossRef Google scholar
[8]
Mountoufaris G, Canzio D, Nwakeze CL, Chen WV, Maniatis T (2018) Writing, reading, and translating the clustered protocadherin cell surface recognition code for neural circuit assembly. Annu Rev Cell Dev Biol 34:471–493
CrossRef Google scholar
[9]
Ribich S, Tasic B, Maniatis T (2006) Identification of long-range regulatory elements in the protocadherin-alpha gene cluster. Proc Natl Acad Sci USA 103:19719–19724
CrossRef Google scholar
[10]
Rowley MJ, Corces VG (2018) Organizational principles of 3D genome architecture. Nat Rev Genet 19:789–800
CrossRef Google scholar
[11]
Shou J, Li J, Liu Y, Wu Q (2018) Precise and predictable CRISPR chromosomal rearrangements reveal principles of Cas9-mediated nucleotide insertion. Mol Cell 71(498–509):e494
CrossRef Google scholar
[12]
Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M, Noonan JP, Zhang MQ, Myers RM (2001) Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Genome Res 11:389–404
CrossRef Google scholar
[13]
Wu Q, Guo Y, Lu Y, Li J, Wu Y, Jia Z (2019) Tandem directional CTCF sites balance protocadherin promoter usage. bioRxiv. https://doi.org/10.1101/525543
CrossRef Google scholar
[14]
Yin M, Wang J, Wang M, Li X, Zhang M, Wu Q, Wang Y (2017) Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites. Cell Res 27:1365–1377
CrossRef Google scholar
[15]
Yokota S, Hirayama T, Hirano K, Kaneko R, Toyoda S, Kawamura Y, Hirabayashi M, Hirabayashi T, Yagi T (2011) Identification of the cluster control region for the protocadherin-beta genes located beyond the protocadherin-gamma cluster. J Biol Chem 286:31885–31895
CrossRef Google scholar

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