The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies

Lei Wang; Wei Wu; Qi Gu; Zengping Liu; Qiyou Li; Zhongwen Li; Jinhui Fang; Wenjing Liu; Jun Wu; Ying Zhang; Liu Wang; Haiwei Xu; Wei Li; Baoyang Hu; Qi Zhou; Zhengqin Yin; Jie Hao

doi:10.1007/s13238-018-0606-8

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Protein Cell ›› 2019, Vol. 10 ›› Issue (6) : 455-460. DOI: 10.1007/s13238-018-0606-8

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The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies

Lei Wang¹^,²^,⁴^,⁶ ,
Wei Wu³ ,
Qi Gu⁵ ,
Zengping Liu³ ,
Qiyou Li³ ,
Zhongwen Li¹^,²^,⁴^,⁶ ,
Jinhui Fang²^,⁴^,⁶ ,
Wenjing Liu²^,⁴^,⁶ ,
Jun Wu²^,⁴^,⁶ ,
Ying Zhang² ,
Liu Wang¹^,²^,⁴^,⁶ ,
Haiwei Xu³ ,
Wei Li¹^,²^,⁴^,⁶ ,
Baoyang Hu¹^,²^,⁴^,⁶ ,
Qi Zhou¹^,²^,⁴^,⁶ ,
Zhengqin Yin³ ,
Jie Hao²^,⁴^,⁶

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Lei Wang, Wei Wu, Qi Gu, Zengping Liu, Qiyou Li, Zhongwen Li, Jinhui Fang, Wenjing Liu, Jun Wu, Ying Zhang, Liu Wang, Haiwei Xu, Wei Li, Baoyang Hu, Qi Zhou, Zhengqin Yin, Jie Hao. The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies. Protein Cell, 2019, 10(6): 455‒460 https://doi.org/10.1007/s13238-018-0606-8

References

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[1]	Andrews PW, Cavagnaro J, Deans R, Feigal E, Horowitz E, Keating A, Rao M, Turner M, Wilmut I, Yamanaka S (2014) Harmonizing standards for producing clinical-grade therapies from pluripotent stem cells. Nat Biotechnol 32:724–726 CrossRef Google scholar

[2]

Diniz B, Thomas P, Thomas B, Ribeiro R, Hu Y, Brant R, Ahuja A, Zhu D, Liu L, Koss M (2013) Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer. Invest Ophthalmol Vis Sci 54:5087–5096

CrossRef Google scholar

[3]	da Cruz L, Fynes K, Georgiadis O, Kerby J, Luo YH, Ahmado A, Vernon A, Daniels JT, Nommiste B, Hasan SM (2018) Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration. Nat Biotechnol 36:328–337 CrossRef Google scholar

[4]	Gu Q, Wang J, Wang L, Liu ZX, Zhu WW, Tan YQ, Han WF, Wu J, Feng CJ, Fang JH (2017) Accreditation of biosafe clinicalgrade human embryonic stem cells according to Chinese regulations. Stem Cell Reports 9:366–380 CrossRef Google scholar

[5]	Kashani AH, Lebkowski JS, Rahhal FM, Avery RL, Salehi-Had H, Dang W, Lin CM, Mitra D, Zhu D, Thomas BB (2018) A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration. Sci Transl Med 10: eaao4097 CrossRef Google scholar

[6]	Kuriyan AE, Albini TA, Townsend JH, Rodriguez M, Pandya HK, Leonard RE 2nd, Parrott MB, Rosenfeld PJ, Flynn HW Jr, Goldberg JL (2017) Vision loss after intravitreal injection of autologous “stem cells” for AMD. N Engl J Med 376:1047–1053 CrossRef Google scholar

[7]	Liu Y, Xu HW, Wang L, Li SY, Zhao CJ, Hao J, Li QY, Zhao TT, Wu W, Wang Y (2018) Human embryonic stem cell-derived retinal pigment epithelium transplants as a potential treatment for wet age-related macular degeneration. Cell Discov 4:50 CrossRef Google scholar

[8]	Maruotti J, Wahlin K, Gorrell D, Bhutto I, Lutty G, Zack DJ (2013) A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells. Stem Cells Transl Med 2:341–354 CrossRef Google scholar

[9]	Schwartz SD, Hubschman JP, Heilwell G, Franco-Cardenas V, Pan CK, Ostrick RM, Mickunas E, Gay R, Klimanskaya I, Lanza R (2012) Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet 379:713–720 CrossRef Google scholar

[10]

Schwartz SD, Regillo CD, Lam BL, Eliott D, Rosenfeld PJ, Gregori NZ, Hubschman JP, Davis JL, Heilwell G, Spirn M (2015) Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt’s macular dystrophy: follow-up of two open-label phase 1/2 studies. Lancet 385:509–516

CrossRef Google scholar

[11]	Song WK, Park KM, Kim HJ, Lee JH, Choi J, Chong SY, Shim SH, Del Priore LV, Lanza R (2015) Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: preliminary results in Asian patients. Stem Cell Reports 4:860–872 CrossRef Google scholar

[12]

Stanzel BV, Liu Z, Somboonthanakij S, Wongsawad W, Brinken R, Eter N, Corneo B, Holz FG, Temple S, Stern JH (2014) Human RPE stem cells grown into polarized RPE monolayers on a polyester matrix are maintained after grafting into rabbit subretinal space. Stem Cell Reports 2:64–77

CrossRef Google scholar

[13]	Strauss O (2005) The retinal pigment epithelium in visual function. Physiol Rev 85:845–881 CrossRef Google scholar

[14]	Unger C, Skottman H, Blomberg P, Dilber MS, Hovatta O (2008) Good manufacturing practice and clinical-grade human embryonic stem cell lines. Hum Mol Genet 17:R48–R53 CrossRef Google scholar