Channel activity of mirror-image M2 proton channel of influenza A virus is blocked by achiral or chiral inhibitors

References

[1] Bohannon J (2010) Mirror-image cells could transform science-or kill us all. Wired

[2] Chang HN, Liu BY, Qi YK, Zhou Y, Chen YP, Pan KM, Li WW, Zhou XM, Ma WW, Fu CY (2015) Blocking of the PD-1/PD-L1 Interaction by a D-Peptide antagonist for cancer immunotherapy. Angew Chem Int Ed 54:11760–11764

[3] Drakopoulos A, Tzitzoglaki C, Ma C, Freudenberger K, Hoffmann A, Hu Y, Gauglitz G, Schmidtke M, Wang J, Kolocouris A (2017) Affinity of rimantadine enantiomers against Influenza A/M2 protein revisited. ACS Med Chem Lett 8:145–150

[4] Fang GM, Li YM, Huang F, Shen F, Huang YC, Li JB, Lin Y, Cui HK, Liu L (2011) Protein chemical synthesis by ligation of peptide hydrazides. Angew Chem Int Ed 50:7645–7649

[5] Lane N, Martin WF (2012) The origin of membrane bioenergetics. Cell 151:1406–1416

[6] Milton RCD, Milton SCF, Kent SBH (1992) Total chemical synthesis of a D-enzyme: the enantiomers of HIV-1 protease show reciprocal chiral substrate specificity. Science 256:1445–1448

[7] Pan M, Gao S, Zheng Y, Tan X, Lan H, Tan X, Sun D, Lu L, Wang T, Zheng Q (2016) Quasi-racemic X-ray structures of K27-linked ubiquitin chains prepared by total chemical synthesis. J Am Chem Soc 138:7429–7435

[8] Schumacher TNM, Mayr LM, Minor DL Jr, Milhollen MA, Burgess MW, Kim PS (1996) Identification of D-peptide ligands through mirror-image phage display. Science 271:1854–1857

[9] Szostak JW, Bartel DP, Luisi PL (2001) Synthesizing life. Nature 409:387–390

[10] Tang S, Zuo C, Huang DL, Cai XY, Zhang LH, Tian Cl, Zheng JS, Liu L (2017) Chemical synthesis of membrane proteins via the removable backbone modification method. Nat Protoc 12:2554–2569

[11] Wang C, Takeuchi K, Pinto LH, Lamb RA (1993) Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block. J Virol 67:5585–5594

[12] Wang Z, Xu W, Liu L, Zhu TF (2016) A synthetic molecular system capable of mirror-image genetic replication and transcription. Nat Chem 8:698–704

[13] Weinstock MT, Jacobsen MT, Kay MS (2014) Synthesis and folding of a mirror-image enzyme reveals ambidextrous chaperone activity. Proc Natl Acad Sci USA 111:11679–11684

[14] Xu W, Jiang W, Wang J, Yu L, Chen J, Liu X, Liu L, Zhu TF (2017) Total chemical synthesis of a thermostable enzyme capable of polymerase chain reaction. Cell Discov 3:17008

[15] Zheng JS, Yu M, Qi YK, Tang S, Shen F, Wang ZP, Xiao L, Zhang LH, Tian CL, Liu L (2014) Expedient total synthesis of small to medium-sized membrane proteins via Fmoc chemistry. J Am Chem Soc 136:3695–3704

RIGHTS & PERMISSIONS

The Author(s) 2018