GCN2 deficiency protects mice from denervation-induced skeletal muscle atrophy via inhibiting FoxO3a nuclear translocation

References

[1] Bauer JM, Verlaan S, Bautmans I, Brandt K, Donini LM, Maggio M, McMurdo ME, Mets T, Seal C, Wijers SL (2015) Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 16:740–747

[2] Bertaggia E, Coletto L, Sandri M (2012) Posttranslational modifications control FoxO3 activity during denervation. Am J Physiol Cell Physiol 302:C587–C596

[3] English KL, Mettler JA, Ellison JB, Mamerow MM, Arentson-Lantz E, Pattarini JM, Ploutz-Snyder R, Sheffield-Moore M, Paddon-Jones D (2016) Leucine partially protects muscle mass and function during bed rest in middle-aged adults. Am J Clin Nutr 103:465–473

[4] Guo Y, Meng J, Tang Y, Wang T, Wei B, Feng R, Gong B, Wang H, Ji G, Lu Z (2016) AMP-activated kinase alpha2 deficiency protects mice from denervation-induced skeletal muscle atrophy. Arch Biochem Biophys 600:56–60

[5] Jang J, Yun HY, Park J, Lim K (2015) Protective effect of branched chain amino acids on hindlimb suspension-induced muscle atrophy in growing rats. J Exerc Nutr Biochem 19:183–189

[6] Kamata S, Yamamoto J, Kamijo K, Ochiai T, Morita T, Yoshitomi Y, Hagiya Y, Kubota M, Ohkubo R, Kawaguchi M (2014) Dietary deprivation of each essential amino acid induces differential systemic adaptive responses in mice. Mol Nutr Food Res 58:1309–1321

[7] Maki T, Yamamoto D, Nakanishi S, Iida K, Iguchi G, Takahashi Y, Kaji H, Chihara K, Okimura Y (2012) Branched-chain amino acids reduce hindlimb suspension-induced muscle atrophy and protein levels of atrogin-1 and MuRF1 in rats. Nutr Res 32:676–683

[8] Ribeiro CB, Christofoletti DC, Pezolato VA, de Cassia Marqueti Durigan R, Prestes J, Tibana RA, Pereira EC, de Sousa Neto IV, Durigan JL, da Silva CA (2015) Leucine minimizes denervationinduced skeletal muscle atrophy of rats through akt/mtor signaling pathways. Front Physiol 6:73

[9] Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL (2004) Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117:399–412

[10] Sood R, Porter AC, Olsen DA, Cavener DR, Wek RC (2000) A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Genetics 154:787–801

[11] Tsien C, Davuluri G, Singh D, Allawy A, Ten Have GA, Thapaliya S, Schulze JM, Barnes D, McCullough AJ, Engelen MP (2015) Metabolic and molecular responses to leucine-enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis. Hepatology 61:2018–2029

[12] Wei B, Dui W, Liu D, Xing Y, Yuan Z, Ji G (2013) MST1, a key player, in enhancing fast skeletal muscle atrophy. BMC Biol 11:12

[13] Wek SA, Zhu S, Wek RC (1995) The histidyl-tRNA synthetaserelated sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids. Mol Cell Biol 15:4497–4506

[14] Yamamoto D, Maki T, Herningtyas EH, Ikeshita N, Shibahara H, Sugiyama Y, Nakanishi S, Iida K, Iguchi G, Takahashi Y (2010) Branched-chain amino acids protect against dexamethasone-induced soleus muscle atrophy in rats. Muscle Nerve 41:819–827

[15] Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL (2007) FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab 6:472–483

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