Human germ line editing—roles and responsibilities

References

[1] Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM et al(2015) Safeguarding gene drive experiments in the laboratory.Science 349:927–929

[2] Anderson WF (1985) Human gene therapy: scientific and ethical considerations. J Med Philos 10:275–291

[3] Cressey D, Abbott A, Ledford H (2015) UK scientists apply for licence to edit genes in human embryos. Nature. Accessed 20 Oct 2015

[4] Davis KM, Pattanayak V, Thompson DB, Zuris JA, Liu DR (2015)Small molecule-triggered Cas9 protein with improved genomeediting specificity. Nat Chem Biol 11:316–318

[5] EuroStemCell (2015) Regulation of stem cell research in Europe.Accessed 20Oct 2015

[6] Fan Y, Li R, Huang J, Zhao H-C, Ding T, Sun X, Yu Y, Qiao J (2014)Improved efficiency of microsurgical enucleated tripronuclear zygotes development and embryonic stem cell derivation by supplementing epidermal growth factor, brain-derived neurotrophic factor and insulin-like growth factor-1. Stem Cells Dev 23:563–575

[7] Fletcher JC (1985) Ethical issues in and beyond prospective trials of human gene therapy. J Med Philos 10:293–309

[8] Fowler PA, Childs AJ, Courant F, MacKenzie A, Rhind SM, Antignac JP, Le Bizec B, Filis P, Evans F, Flannigan S, Maheshwari A,Bhattacharya S, Monteiro A, Anderson RA, O’Shaughnessy PJ(2014) In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling. Hum Reprod 29:1471–1489

[9] Hedrick PW (2012) What is the evidence for heterozygote advantage selection? Trends Ecol Evol 27:698–704

[10] Human Genome 1989-90 Program Report (1990) U.S. Department of Energy, Office of Energy Research, Office of Health and Environmental Research. Washington, D.C. Accessed20 Oct 2015

[11] International Bioethics Committee (IBC) (2015) Report of the IBC on Updating Its Reflection on the Human Genome and Human Rights. Paris 2 Oct 2015.Accessed 20 Oct 2015

[12] Isasi R, Knoppers BM (2015) Oversight of human inheritable genome modification. Nat Biotechnol 33:454–455

[13] Kattera S, Chen C (2003) Normal birth after microsurgical enucleation of tripronuclear zygotes: case report. Hum Reprod 18:1319–1322

[14] Lanphier E, Urnov F (2015) Don’t edit the human germ line. Nature 519:410–411

[15] Liang P, Xu Y, Zhang X, Ding C, Huang R, Zhang Z, Lv J, Xie X,Chen Y, Li Y et al (2015) CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein Cell 6:363–372

[16] Lunshof JE (2015) Regulate gene editing in wild animals. Nature 521:127

[17] Lunshof JE, Zimmerli WC (1992) The Human Genome—Fundamental Research, Germline Modification and Ethics (http://libgallery.cshl.edu/items/show/70297). Accessed 20 Oct 2015

[18] Maruyama T, Dougan SK, Truttmann MC, Bilate AM, Ingram JR,Ploegh HL (2015) Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nat Biotechnol 33:538–542

[19] Oye KA, Esvelt K, Appleton E, Catteruccia F, Church GM, Kuiken T et al (2015) Regulating gene drives. Science 345:626–628

[20] Reardon S (2015) US Congress moves to block human-embryo editing. Nature.Accessed 20 Oct 2015

[21] Statement on NIH funding of research using gene-editing technologies in human embryos (2015). Accessed20 Oct 2015

[22] The Embryo Protection Act (1990).Accessed 20 Oct 2015

[23] The ISSCR Statement on Human Germline Modification (2015).Accessed 20 Oct 2015

[24] Valverde G, Zhou H, Lippold S, de Filippo C, Tang K, López Herráez D, Li J, Stoneking M (2015) A novel candidate region for genetic adaptation to high altitude in Andean populations. PLoS One 10:e0125444.

[25] Yang L, Grishin D, Wang G, Aach J, Zhang CZ, Chari R, Homsy J,Cai X, Zhao Y, Fan JB, Seidman C, Seidman J, Pu W, Church G(2014) Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells. Nat Commun 5:5507

[26] Yauk CL, Lambert IB, Meek ME, Douglas GR, Marchetti F (2015)Development of the adverse outcome pathway “alkylation of DNA in male premeiotic germ cells leading to heritable mutations”using the OECD’s users’ handbook supplement. Environ Mol Mutagen. 2015May 22. [Epub ahead of print]

RIGHTS & PERMISSIONS

The Author(s) 2015. This article is published with open access at Springerlink.com and journal.hep.com.cn