Human germ line editing—roles and responsibilities

Jeantine E. Lunshof

PDF(244 KB)
PDF(244 KB)
Protein Cell ›› 2016, Vol. 7 ›› Issue (1) : 7-10. DOI: 10.1007/s13238-015-0224-7
COMMENTARY
COMMENTARY

Human germ line editing—roles and responsibilities

Author information +
History +

Cite this article

Download citation ▾
Jeantine E. Lunshof. Human germ line editing—roles and responsibilities. Protein Cell, 2016, 7(1): 7‒10 https://doi.org/10.1007/s13238-015-0224-7

References

[1]
Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM et al(2015) Safeguarding gene drive experiments in the laboratory.Science 349:927–929
CrossRef Google scholar
[2]
Anderson WF (1985) Human gene therapy: scientific and ethical considerations. J Med Philos 10:275–291
CrossRef Google scholar
[3]
Cressey D, Abbott A, Ledford H (2015) UK scientists apply for licence to edit genes in human embryos. Nature. Accessed 20 Oct 2015
CrossRef Google scholar
[4]
Davis KM, Pattanayak V, Thompson DB, Zuris JA, Liu DR (2015)Small molecule-triggered Cas9 protein with improved genomeediting specificity. Nat Chem Biol 11:316–318
CrossRef Google scholar
[5]
EuroStemCell (2015) Regulation of stem cell research in Europe.Accessed 20Oct 2015
[6]
Fan Y, Li R, Huang J, Zhao H-C, Ding T, Sun X, Yu Y, Qiao J (2014)Improved efficiency of microsurgical enucleated tripronuclear zygotes development and embryonic stem cell derivation by supplementing epidermal growth factor, brain-derived neurotrophic factor and insulin-like growth factor-1. Stem Cells Dev 23:563–575
CrossRef Google scholar
[7]
Fletcher JC (1985) Ethical issues in and beyond prospective trials of human gene therapy. J Med Philos 10:293–309
CrossRef Google scholar
[8]
Fowler PA, Childs AJ, Courant F, MacKenzie A, Rhind SM, Antignac JP, Le Bizec B, Filis P, Evans F, Flannigan S, Maheshwari A,Bhattacharya S, Monteiro A, Anderson RA, O’Shaughnessy PJ(2014) In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling. Hum Reprod 29:1471–1489
CrossRef Google scholar
[9]
Hedrick PW (2012) What is the evidence for heterozygote advantage selection? Trends Ecol Evol 27:698–704
[10]
Human Genome 1989-90 Program Report (1990) U.S. Department of Energy, Office of Energy Research, Office of Health and Environmental Research. Washington, D.C. Accessed20 Oct 2015
[11]
International Bioethics Committee (IBC) (2015) Report of the IBC on Updating Its Reflection on the Human Genome and Human Rights. Paris 2 Oct 2015.Accessed 20 Oct 2015
[12]
Isasi R, Knoppers BM (2015) Oversight of human inheritable genome modification. Nat Biotechnol 33:454–455
CrossRef Google scholar
[13]
Kattera S, Chen C (2003) Normal birth after microsurgical enucleation of tripronuclear zygotes: case report. Hum Reprod 18:1319–1322
CrossRef Google scholar
[14]
Lanphier E, Urnov F (2015) Don’t edit the human germ line. Nature 519:410–411
CrossRef Google scholar
[15]
Liang P, Xu Y, Zhang X, Ding C, Huang R, Zhang Z, Lv J, Xie X,Chen Y, Li Y et al (2015) CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein Cell 6:363–372
CrossRef Google scholar
[16]
Lunshof JE (2015) Regulate gene editing in wild animals. Nature 521:127
CrossRef Google scholar
[17]
Lunshof JE, Zimmerli WC (1992) The Human Genome—Fundamental Research, Germline Modification and Ethics (http://libgallery.cshl.edu/items/show/70297). Accessed 20 Oct 2015
[18]
Maruyama T, Dougan SK, Truttmann MC, Bilate AM, Ingram JR,Ploegh HL (2015) Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nat Biotechnol 33:538–542
CrossRef Google scholar
[19]
Oye KA, Esvelt K, Appleton E, Catteruccia F, Church GM, Kuiken T et al (2015) Regulating gene drives. Science 345:626–628
[20]
Reardon S (2015) US Congress moves to block human-embryo editing. Nature.Accessed 20 Oct 2015
CrossRef Google scholar
[21]
Statement on NIH funding of research using gene-editing technologies in human embryos (2015). Accessed20 Oct 2015
[22]
The Embryo Protection Act (1990).Accessed 20 Oct 2015
[23]
The ISSCR Statement on Human Germline Modification (2015).Accessed 20 Oct 2015
[24]
Valverde G, Zhou H, Lippold S, de Filippo C, Tang K, López Herráez D, Li J, Stoneking M (2015) A novel candidate region for genetic adaptation to high altitude in Andean populations. PLoS One 10:e0125444.
CrossRef Google scholar
[25]
Yang L, Grishin D, Wang G, Aach J, Zhang CZ, Chari R, Homsy J,Cai X, Zhao Y, Fan JB, Seidman C, Seidman J, Pu W, Church G(2014) Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells. Nat Commun 5:5507
CrossRef Google scholar
[26]
Yauk CL, Lambert IB, Meek ME, Douglas GR, Marchetti F (2015)Development of the adverse outcome pathway “alkylation of DNA in male premeiotic germ cells leading to heritable mutations”using the OECD’s users’ handbook supplement. Environ Mol Mutagen. 2015May 22. [Epub ahead of print]
CrossRef Google scholar

RIGHTS & PERMISSIONS

2016 The Author(s) 2015. This article is published with open access at Springerlink.com and journal.hep.com.cn
AI Summary AI Mindmap
PDF(244 KB)

Accesses

Citations

Detail

Sections
Recommended

/