To be EndMT or not to be, that is the question in pulmonary hypertension

Jianhua Xiong

PDF(700 KB)
PDF(700 KB)
Protein Cell ›› 2015, Vol. 6 ›› Issue (8) : 547-550. DOI: 10.1007/s13238-015-0183-z
NEWS AND VIEWS
NEWS AND VIEWS

To be EndMT or not to be, that is the question in pulmonary hypertension

Author information +
History +

Cite this article

Download citation ▾
Jianhua Xiong. To be EndMT or not to be, that is the question in pulmonary hypertension. Protein Cell, 2015, 6(8): 547‒550 https://doi.org/10.1007/s13238-015-0183-z

References

[1]
Arciniegas E, Neves CY, Carrillo LM, Zambrano EA, Ramirez R (2005) Endothelial-mesenchymal transition occurs during embryonic pulmonary artery development. Endothelium 12: 193-200
CrossRef Google scholar
[2]
Arciniegas E, Frid MG, Douglas IS, Stenmark KR (2007) Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 293: L1-L8
CrossRef Google scholar
[3]
Atkinson C, Stewart S, Upton PD, Machado R, Thomson JR, Trembath RC, Morrell NW (2002) Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation 105: 1672-1678
CrossRef Google scholar
[4]
Austin ED, Loyd JE (2014) The genetics of pulmonary arterial hypertension. Circ Res 115: 189-202
CrossRef Google scholar
[5]
Budhiraja R, Tuder RM, Hassoun PM (2004) Endothelial dysfunction in pulmonary hypertension. Circulation 109: 159-165
CrossRef Google scholar
[6]
Burton VJ, Ciuclan LI, Holmes AM, Rodman DM, Walker C, Budd DC (2011) Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function. Blood 117: 333-341
CrossRef Google scholar
[7]
Choi SH, Hong ZY, Nam JK, Jang J, Lee HJ, Yoo RJ, Lee YJ, Park S, Ji YH, Lee YS (2015) A hypoxia-induced vascular endothelial-to-mesenchymal transition in development of radiation- induced pulmonary fibrosis. Clin Cancer Res
CrossRef Google scholar
[8]
Dudek SM, Garcia JG (2001) Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 91(1985): 1487-1500
[9]
Good RB, Gilbane AJ, Trinder SL, Denton CP, Coghlan G, Abraham DJ, Holmes AM (2015) Endothelial to mesenchymal transition contributes to endothelial dysfunction in pulmonary artery hypertension. Am J Pathol
CrossRef Google scholar
[10]
Hashimoto N, Phan SH, Imaizumi K, Matsuo M, Nakashima H, Kawabe T, Shimokata K, Hasegawa Y (2010) Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 43: 161-172
CrossRef Google scholar
[11]
International PPHC, Lane KB, Machado RD, Pauciulo MW, Thomson JR, Phillips JA 3rd, Loyd JE, Nichols WC, Trembath RC (2000) Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. Nat Genet 26: 81-84
CrossRef Google scholar
[12]
Li Z, Wermuth PJ, Benn BS, Lisanti MP, Jimenez SA (2013) Caveolin-1 deficiency induces spontaneous endothelial-to-mesenchymal transition in murine pulmonary endothelial cells in vitro. Am J Pathol 182: 325-331
CrossRef Google scholar
[13]
Lin F, Wang N, Zhang TC (2012) The role of endothelial-mesenchymal transition in development and pathological process. IUBMB Life 64: 717-723
CrossRef Google scholar
[14]
Mehari A, Valle O, Gillum RF (2014) Trends in pulmonary hypertension mortality and morbidity. Pulm Med 2014: 105864
CrossRef Google scholar
[15]
Qiao L, Nishimura T, Shi L, Sessions D, Thrasher A, Trudell JR, Berry GJ, Pearl RG, Kao PN (2014) Endothelial fate mapping in mice with pulmonary hypertension. Circulation 129: 692-703
CrossRef Google scholar
[16]
Ranchoux B, Antigny F, Rucker-Martin C, Hautefort A, Pechoux C, Bogaard HJ, Dorfmuller P, Remy S, Lecerf F, Plante S (2015) Endothelial-to-mesenchymal transition in pulmonary hypertension. Circulation 131: 1006-1018
CrossRef Google scholar
[17]
Reynolds AM, Holmes MD, Danilov SM, Reynolds PN (2012) Targeted gene delivery of BMPR2 attenuates pulmonary hypertension. Eur Respir J 39: 329-343
CrossRef Google scholar
[18]
Rieder F, Kessler SP, West GA, Bhilocha S, de la Motte C, Sadler TM, Gopalan B, Stylianou E, Fiocchi C (2011) Inflammation-induced endothelial-to-mesenchymal transition: a novel mechanism of intestinal fibrosis. Am J Pathol 179: 2660-2673
CrossRef Google scholar
[19]
Rockey DC, Bell PD, Hill JA (2015) Fibrosis—a common pathway to organ injury and failure. N Engl J Med 372: 1138-1149
CrossRef Google scholar
[20]
Schermuly RT, Ghofrani HA, Wilkins MR, Grimminger F (2011) Mechanisms of disease: pulmonary arterial hypertension. Nat Rev Cardiol 8: 443-455
CrossRef Google scholar
[21]
Schultze AE, Roth RA (1993) Fibrinolytic activity in blood and lungs of rats treated with monocrotaline pyrrole. Toxicol Appl Pharmacol 121: 129-137
CrossRef Google scholar
[22]
Schultze AE, Emeis JJ, Roth RA (1996) Cellular fibronectin and von Willebrand factor concentrations in plasma of rats treated with monocrotaline pyrrole. Biochem Pharmacol 51: 187-191
CrossRef Google scholar
[23]
Smith P, Heath D (1979) Electron microscopy of the plexiform lesion. Thorax 34: 177-186
CrossRef Google scholar
[24]
Tozzi CA, Christiansen DL, Poiani GJ, Riley DJ (1994) Excess collagen in hypertensive pulmonary arteries decreases vascular distensibility. Am J Respir Crit Care Med 149: 1317-1326
CrossRef Google scholar
[25]
van Meeteren LA, ten Dijke P (2012) Regulation of endothelial cell plasticity by TGF-beta. Cell Tissue Res 347: 177-186
CrossRef Google scholar
[26]
Weibel ER (2012) Fifty years of Weibel-Palade bodies: the discovery and early history of an enigmatic organelle of endothelial cells. J Thromb Haemost 10: 979-984
CrossRef Google scholar
[27]
Yu W, Liu Z, An S, Zhao J, Xiao L, Gou Y, Lin Y, Wang J (2014) The endothelial-mesenchymal transition (EndMT) and tissue regeneration. Curr Stem Cell Res Ther 9: 196-204
CrossRef Google scholar
[28]
Zhu P, Huang L, Ge X, Yan F, Wu R, Ao Q (2006) Transdifferentiation of pulmonary arteriolar endothelial cells into smooth muscle-like cells regulated by myocardin involved in hypoxia-induced pulmonary vascular remodelling. Int J Exp Pathol 87: 463-474
CrossRef Google scholar

RIGHTS & PERMISSIONS

2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
AI Summary AI Mindmap
PDF(700 KB)

Accesses

Citations

Detail

Sections
Recommended

/