A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells

Zhichao Ding , Lina Sui , Ruotong Ren , Yanjun Liu , Xiuling Xu , Lina Fu , Ruijun Bai , Tingting Yuan , Ying Hao , Weiqi Zhang , Huize Pan , Wensu Liu , Han Yu , Concepcion Rodriguez Esteban , Xiaobing Yu , Ze Yang , Jian Li , Xiaomin Wang , Juan Carlos Izpisua Belmonte , Guang-Hui Liu , Fei Yi , Jing Qu

Protein Cell ›› 2015, Vol. 6 ›› Issue (5) : 386 -389.

PDF (827KB)
Protein Cell ›› 2015, Vol. 6 ›› Issue (5) : 386 -389. DOI: 10.1007/s13238-014-0117-1
LETTER
LETTER

A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells

Author information +
History +
PDF (827KB)

Cite this article

Download citation ▾
Zhichao Ding, Lina Sui, Ruotong Ren, Yanjun Liu, Xiuling Xu, Lina Fu, Ruijun Bai, Tingting Yuan, Ying Hao, Weiqi Zhang, Huize Pan, Wensu Liu, Han Yu, Concepcion Rodriguez Esteban, Xiaobing Yu, Ze Yang, Jian Li, Xiaomin Wang, Juan Carlos Izpisua Belmonte, Guang-Hui Liu, Fei Yi, Jing Qu. A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells. Protein Cell, 2015, 6(5): 386-389 DOI:10.1007/s13238-014-0117-1

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Buganim Y, Markoulaki S, van Wietmarschen N, Hoke H, Wu T, Ganz K, Akhtar-Zaidi B, He YP, Abraham BJ, Porubsky D (2014) The developmental potential of iPSCs is greatly influenced by reprogramming factor selection. Cell stem cell15: 295-309

[2]

Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, Zhao T, Ye J, Yang W, Liu K (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science341: 651-654

[3]

Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A (2009) A chemical platform for improved induction of human iPSCs. Nat methods6: 805-808

[4]

Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C (2011) Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature472: 221-225

[5]

Liu GH, Qu J, Suzuki K, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz S, Zhang W (2012) Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature491: 603-607

[6]

Liu GH, Suzuki K, Li M, Qu J, Montserrat N, Tarantino C, Gu Y, Yi F, Xu X, Zhang W (2014) Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs. Nat Commun5: 4330

[7]

Mali P, Chou BK, Yen J, Ye Z, Zou J, Dowey S, Brodsky RA, Ohm JE, Yu W, Baylin SB (2010) Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem cells28: 713-720

[8]

Okita K, Matsumura Y, Sato Y, Okada A, Morizane A, Okamoto S, Hong H, Nakagawa M, Tanabe K, Tezuka K (2011) A more efficient method to generate integration-free human iPS cells. Nat methods8: 409-412

[9]

Patel M, Yang S (2010) Advances in reprogramming somatic cells to induced pluripotent stem cells. Stem cell rev6: 367-380

[10]

Raya A, Rodriguez-Piza I, Guenechea G, Vassena R, Navarro S, Barrero MJ, Consiglio A, Castella M, Rio P, Sleep E (2009) Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature460: 53-59

[11]

Sanchez Alvarado A, Yamanaka S (2014) Rethinking differentiation: stem cells, regeneration, and plasticity. Cell157: 110-119

[12]

Seki T, Yuasa S, Fukuda K (2012) Generation of induced pluripotent stem cells from a small amount of human peripheral blood using a combination of activated T cells and Sendai virus. Nat Protoc7: 718-728

[13]

Sui L, Liu GH, Izpisua Belmonte JC (2013) hESC-derived pancreatic progenitors. Cell res23: 592-594

[14]

Xue Y, Cai X, Wang L, Liao B, Zhang H, Shan Y, Chen Q, Zhou T, Li X, Hou J (2013) Generating a non-integrating human induced pluripotent stem cell bank from urine-derived cells. PloS One8: e70573

[15]

Zhang D, Jiang W, Liu M, Sui X, Yin X,Chen S, Shi Y, Deng H (2009) Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell res19: 429-438

RIGHTS & PERMISSIONS

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

AI Summary AI Mindmap
PDF (827KB)

Supplementary files

Supplementary Material

745

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/