The immunology connection—my first T cell receptor structure projects

References

[1] Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC (1996) Structure of the complex between human T-cell receptor, viral peptide and HLA-A2 [comment]. Nature384: 134-141

[2] Garcia KC, Degano M, Stanfleld RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA (1996) An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex [see comments]. Science274: 209-219

[3] Kim ST, Touma M, Takeuchi K, Sun ZY, Dave VP, Kappes DJ, Wagner G, Reinherz EL (2010) Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors. J Immunol185: 2951-2959

[4] Pang SS, Berry R, Chen Z, Kjer-Nielsen L, Perugini MA, King GF, Wang C, Chew SH, La Gruta NL, Williams NK, Beddoe T, Tiganis T, Cowieson NP, Godfrey DI, Purcell AW, Wilce MC, McCluskey J, Rossjohn J (2010) The structural basis for autonomous dimerization of the pre-T-cell antigen receptor. Nature467: 844-848

[5] Reinherz EL, Kung PC, Goldstein G, Schlossman SF (1979) Separation of functional subsets of human T cells by a monoclonal antibody. Proc Natl Acad Sci USA76: 4061-4065

[6] Reinherz EL, Tan K, Tang L, Kern P, Liu J, Xiong Y, Hussey RE, Smolyar A, Hare B, Zhang R, Joachimiak A, Chang HC, Wagner G, Wang J (1999) The crystal structure of a T cell receptor in complex with peptide and MHC class II [see comments]. Science286: 1913-1921

[7] Ryu SE, Kwong PD, Truneh A, Porter TG, Arthos J, Rosenberg M, Dai XP, Xuong NH, Axel R, Sweet RW (1990) Crystal structure of an HIV-binding recombinant fragment of human CD4 [see comments]. Nature348: 419-426

[8] Stanley P (1989) Chinese hamster ovary cell mutants with multiple glycosylation defects for production of glycoproteins with minimal carbohydrate heterogeneity. Mol Cell Biol9: 377-383

[9] Teng MK, Smolyar A, Tse AG, Liu JH, Liu J, Hussey RE, Nathenson SG, Chang HC, Reinherz EL, Wang J-H (1998) Identiflcation of a common docking topology with substantial variation among different TCR-peptide-MHC complexes. Curr Biol8: 409-412

[10] Wang J-H, Yan YW, Garrett TP, Liu JH, Rodgers DW, Garlick RL, Tarr GE, Husain Y, Reinherz EL, Harrison SC (1990) Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains [see comments]. Nature348: 411-418

[11] Wang J-H, Lim K, Smolyar A, Teng M, Liu J, Tse AG, Hussey RE, Chishti Y, Thomson CT, Sweet RM, Nathenson SG, Chang HC, Sacchettini JC, Reinherz EL (1998) Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody. Embo J17: 10-26

[12] Wang J-H, Meijers R, Xiong Y, Liu J-H, Sakihama T, Zhang R, Joachimiak A, Reinherz E (2001) Crystal structure of the human CD4 N-terminal two domain fragment complexed to a class II MHC molecule. PNAS98: 10799-10804

[13] Yin Y, Wang XX, Mariuzza RA (2012) Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4. Proc Natl Acad Sci USA109: 5405-5410

RIGHTS & PERMISSIONS

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.