Lysosomal chymotrypsin induces mitochondrial fission in apoptotic cells by proteolytic activation of calcineurin

References

[1] Aits S, Jaattela M (2013) Lysosomal cell death at a glance. J Cell Sci126: 1905-1912

[2] Boya P (2012) Lysosomal function and dysfunction: mechanism and disease. Antioxid Redox Signal17: 766-774

[3] Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T, Kurth MJ, Shaw JT, Hinshaw JE, Green DR (2008) Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell14: 193-204

[4] Cereghetti GM, Stangherlin A, Martins de Brito O, Chang CR, Blackstone C, Bernardi P, Scorrano L (2008) Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci USA105: 15803-15808

[5] Cereghetti GM, Costa V, Scorrano L (2010) Inhibition of Drp1-dependent mitochondrial fragmentation and apoptosis by a polypeptide antagonist of calcineurin. Cell Death Differ17: 1785-1794

[6] Chang CR, Blackstone C (2010) Dynamic regulation of mitochondrial flssion through modiflcation of the dynamin-related protein Drp1. Ann N Y Acad Sci1201: 34-39

[7] Cribbs JT, Strack S (2007) Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial flssion and cell death. EMBO Rep8: 939-944

[8] Green DR, Kroemer G (2004) The pathophysiology of mitochondrial cell death. Science305: 626-629

[9] Miao Q, Sun Y, Wei T, Zhao X, Zhao K, Yan L, Zhang X, Shu H, Yang F (2008) Chymotrypsin B cached in rat liver lysosomes and involved in apoptotic regulation through a mitochondrial pathway. J Biol Chem283: 8218-8228

[10] Moldoveanu T, Follis AV, Kriwacki RW, Green DR (2014) Many players in BCL-2 family affairs. Trends Biochem Sci39: 101-111

[11] Montessuit S, Somasekharan SP, Terrones O, Lucken-Ardjomande S, Herzig S, Schwarzenbacher R, Manstein DJ, Bossy-Wetzel E, Basanez G, Meda P (2010) Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization. Cell142: 889-901

[12] Tait SW, Green DR (2010) Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol11: 621-632

[13] Wang JX, Jiao JQ, Li Q, Long B, Wang K, Liu JP, Li YR, Li PF (2011) miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nat Med17: 71-78

[14] Zhao K, Zhao X, Tu Y, Miao Q, Cao D, Duan W, Sun Y, Wang J, Wei T, Yang F (2010) Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid. Cell Mol Life Sci67: 2665-2678

[15] Zhao K, Zhou H, Zhao X, Wolff DW, Tu Y, Liu H, Wei T, Yang F (2012) Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis. J Lipid Res53: 2102-2114

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