EZH2, an epigenetic driver of prostate cancer

Yeqing Angela Yang1, Jindan Yu1,2()

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Protein Cell ›› 2013, Vol. 4 ›› Issue (5) : 331-341. DOI: 10.1007/s13238-013-2093-2
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REVIEW

EZH2, an epigenetic driver of prostate cancer

  • Yeqing Angela Yang1, Jindan Yu1,2()
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Abstract

The histone methyltransferase EZH2 has been in the limelight of the fi eld of cancer epigenetics for a decade now since it was fi rst discovered to exhibit an elevated expression in metastatic prostate cancer. It persists to attract much scientifi c attention due to its important role in the process of cancer development and its potential of being an effective therapeutic target. Thus here we review the dysregulation of EZH2 in prostate cancer, its function, upstream regulators, downstream effectors, and current status of EZH2-targeting approaches. This review therefore provides a comprehensive overview of EZH2 in the context of prostate cancer.

Keywords

EZH2 / histone methyltransferase / prostate cancer / epigenetics

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Yeqing Angela Yang, Jindan Yu. EZH2, an epigenetic driver of prostate cancer. Prot Cell, 2013, 4(5): 331‒341 https://doi.org/10.1007/s13238-013-2093-2

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