Are hepatocytes endocrine cells?

References

[1] Meex RCR.Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance.Nat Rev Endocrinol2017;13:509-20

[2] Watt MJ,De Nardo W.The liver as an endocrine organ-linking NAFLD and insulin resistance.Endocrine Reviews2019;40:1367-93

[3] Stefan N,Birkenfeld AL,White MF.The role of hepatokines in NAFLD.Cell Metab2023;35:236-52

[4] Flippo KH.Metabolic messengers: FGF21.Nat Metab2021;3:309-17 PMCID:PMC8620721

[5] Song WJ,Wolfe A.Glucagon regulates hepatic kisspeptin to impair insulin secretion.Cell Metab2014;19:667-81 PMCID:PMC4058888

[6] Meex RC,Morris A.Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism.Cell Metab2015;22:1078-89

[7] El Ouaamari A,Gedeon N.SerpinB1 promotes pancreatic β cell proliferation.Cell Metab2016;23:194-205 PMCID:PMC4715773

[8] Tao R,Stöhr O.Inactivating hepatic follistatin alleviates hyperglycemia.Nat Med2018;24:1058-69 PMCID:PMC6039237

[9] Gong XM,Luo J.Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance.Nat Metab2019;1:570-83

[10] Wang Q,Shen H.The hepatokine Tsukushi gates energy expenditure via brown fat sympathetic innervation.Nat Metab2019;1:251-60 PMCID:PMC6750233

[11] Montgomery MK,Devereux C.SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control.Sci Transl Med2020;12:eaaz8048

[12] Zhou B,Ji N,Lu Y.Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis.Nat Metab2022;4:1185-201

[13] Kalra S,Rawal P.Hepatocrinology.Med Sci (Basel)2021;9:39 PMCID:PMC8293374