Advancements in porous organic frameworks based electrochemical sensors for organophosphorus pesticides detection

Abstract

Covalent organic frameworks (COFs) and metal-organic frameworks (MOFs), two important classes of crystalline porous organic frameworks (POFs), are constructed from organic structural units for COFs, and metal ions/clusters coordinated with organic ligands for MOFs, via robust chemical bonds. Due to their outstanding physicochemical properties, including large specific surface area, favorable structural stability, excellent biocompatibility and high porosity, POFs have gained considerable attention in the domain of electrochemical sensing of organophosphorus pesticides (OPs). Through the persistent endeavors of researchers, the construction of POFs-based electrochemical sensors for detecting OPs has made significant advances. Accordingly, this review introduces the dimensional classifications of POFs (one-, two- and three-dimensional POFs), and summarizes the six typical preparation methods to further realize the controllable synthesis of POFs with tunable compositions and structures. More importantly, the research advances in the fabrication of POFs-based non-enzymatic/enzymatic electrochemical sensors and their electrochemical performance for the detection of OPs are emphatically reviewed. In addition, the research progress of other POFs-based electrochemical sensors, including molecularly imprinted polymer (MIP), aptamer based (APT) and electrochemiluminescence (ECL) sensors for the detection of OPs, is also briefly presented. Finally, the prospective research directions for developing high-performance POFs-based electrochemical sensors are outlined to facilitate the accurate, quick, efficient and economical real-time detection of OPs in food matrices.

Keywords

Porous organic frameworks / metal-organic frameworks / covalent organic frameworks / electrochemical sensors / organophosphorus pesticides

References

[1] Castelvecchi D.,Naddaf M.. Chemistry Nobel for scientists who developed massively porous ‘super sponge’ materials Nature 2025 646 522 3

[2] Hoskins B. F.,Robson R.. Infinite polymeric frameworks consisting of three dimensionally linked rod-like segments J. Am. Chem. Soc. 2002 111 5962 4

[3] Yaghi O. M.,Li G.,Li H.. Selective binding and removal of guests in a microporous metal-organic framework Nature 1995 378 703 6

[4] Côté A. P.,Benin A. I.,Ockwig N. W.,O’Keeffe M.,Matzger A. J.,Yaghi O. M.. Porous, crystalline, covalent organic frameworks Science 2005 310 1166 70

[5] Singh A.,K K S.,Bhatnagar A.,Gupta A. K.. Crystalline porous frameworks: advances in synthesis, mechanisms, modifications, and remediation of organic pollutants Sep. Purif. Technol. 2025 353 128588

[6] Jiao L.,Seow J. Y. R.,Skinner W. S.,Wang Z. U.,Jiang H.. Metal-organic frameworks: Structures and functional applications Materials Today 2019 27 43 68

[7] Abuzeid H. R.,El-mahdy A. F.,Kuo S.. Covalent organic frameworks: design principles, synthetic strategies, and diverse applications Giant 2021 6 100054

[8] Larsen A. E.,Noack F.,Powers L. C.. Spillover effects of organic agriculture on pesticide use on nearby fields Science 2024 383 eadf2572

[9] Abubakar, Y., Tijjani, H., Egbuna, C., et al. Pesticides, history, and classification. In Natural Remedies for Pest, Disease and Weed Control; Elsevier, 2020; pp 29-42

[10] Zhang Z.,Zhang Y.,Jayan H..et al. Recent and emerging trends of metal-organic frameworks (MOFs)-based sensors for detecting food contaminants: a critical and comprehensive review Food Chem. 2024 448 139051

[11] Ganie S. Y.,Javaid D.,Hajam Y. A.,Reshi M. S.. Mechanisms and treatment strategies of organophosphate pesticide induced neurotoxicity in humans: a critical appraisal Toxicology 2022 472 153181

[12] Musa Jaber Al-Maliki A.,Masrournia M.,Sanavi Khoshnood R.,Beyramabadi A.. Dispersive micro solid-phase extraction with bimetallic Ni, Zn-MOF sorbent and gas chromatography method for organophosphorus pesticide determination in environmental water samples Microchem. J. 2024 205 111259

[13] Jafari M.,Gholami A.,Akhgari M.. A novel method for the determination of organophosphorus pesticides in urine samples using a combined gas diffusion microextraction (GDME) and gas chromatography-mass spectrometry (GC-MS) technique MethodsX 2025 14 103212

[14] Zhang S.,You Q.,Zhuo X..et al. Rapid and simple determination of organophosphorus pesticides in urine using polydopamine-modified monolithic spin column extraction combined with liquid chromatography-mass spectrometry J. Chromatogr. A. 2023 1696 463959

[15] Shi R.,Li J.,Yu W..et al. Biotinylated fusion protein-streptavidin-peroxidase complex based non-competitive magnetic immunoassay for rapid detection of organophosphorus pesticides Talanta Open 2025 12 100483

[16] Wang J.,Zeng Q.,Cao K.,Cui Y.,Xiao H.,Wang L.. Green synthesis of hawthorn polysaccharide-stabilized Pd@Ru nanozymes for sensitive colorimetric detection of organophosphorus pesticides Int. J. Biol. Macromol. 2025 329 147780

[17] Zhou C.,Feng J.,Tian Y..et al. Non-enzymatic electrochemical sensors based on nanomaterials for detection of organophosphorus pesticide residues Environ. Sci.: Adv. 2023 2 933 56

[18] Kumaravel A.,Chandrasekaran M.. Electrochemical determination of chlorpyrifos on a nano-TiO₂/cellulose acetate composite modified glassy carbon electrode J. Agric. Food Chem. 2015 63 6150 6

[19] Zhang Y.,Wang X.,Wang Y.,Xu N.,Wang X.. Anderson-type polyoxometalate-based sandwich complexes bearing a new “V”-like bis-imidazole-bis-amide ligand as electrochemical sensors and catalysts for sulfide oxidation Polyoxometalates 2022 1 9140004

[20] Liu X. L.,Guo J. W.,Wang Y. W.,Wang A. Z.,Yu X.,Ding L. H.. A flexible electrochemical sensor for paracetamol based on porous honeycomb‐like NiCo‐MOF nanosheets Rare Metals 2023 42 3311 7

[21] Sumithra B.,Saravanan V.,Ramalingan C.,Sivaganesh D.,Lakshmanan P.,Geetha D.. Harnessing sunlight: unlocking superior photocatalytic activity of g-C₃N₄/MnWO₄ heterojunction photocatalysts for degradation of hazardous compounds Tungsten 2024 7 255 67

[22] Duan S.,Wu X.,Shu Z..et al. Curcumin-enhanced MOF electrochemical sensor for sensitive detection of methyl parathion in vegetables and fruits Microchem. J. 2023 184 108182

[23] Wang L.,Wu N.,Wang L.,Song Y.,Ma G.. Accurate detection of organophosphorus pesticides based on covalent organic framework nanofiber with a turn-on strategy Sensor. Actuat. B-Chem. 2022 372 132608

[24] Nangare S. N.,Patil S. R.,Patil A. G..et al. Structural design of nanosize-metal-organic framework-based sensors for detection of organophosphorus pesticides in food and water samples: current challenges and future prospects J. Nanostruct. Chem. 2021 12 729 64

[25] Lu Z.,Wang Y.,Li G.. Covalent organic frameworks-based electrochemical sensors for food safety analysis Biosensors 2023 13 291 PMC9954712

[26] Zheng H.,Yan W.,Zhang J.. Porous organic framework-based materials (MOFs, COFs and HOFs) for lithium-/sodium-/potassium-/zinc-/aluminum-/calcium-ion batteries: a review Electrochem. Energy Rev. 2025 8 3

[27] Huang P.,Hou L. H.,Yang M. Y..et al. One-dimensional covalent organic frameworks: from design, synthesis to applications Angew. Chem. Int. Ed. 2025 64 e202507002

[28] Dai Y.,Zhang G.,Peng Y.,Li Y.,Chi H.,Pang H.. Recent progress in 1D MOFs and their applications in energy and environmental fields Adv. Colloid Interface Sci. 2023 321 103022

[29] Pan X.,Zhu Q.,Yu K..et al. One-dimensional metal-organic frameworks: synthesis, structure and application in electrocatalysis Next Mater. 2023 1 100010

[30] Pezhhanfar S.,Farajzadeh M. A.,Hosseini-Yazdi S. A.,Mogaddam M. R. A.. An all-embracing analytical method comprising modified QuEChERS-dispersive micro-solid-phase extraction-dispersive liquid-liquid microextraction using FeGA MOF for the extraction and preconcentration of pesticides simultaneously from juice and flesh of watermelon Anal. Sci. 2023 39 1201 14

[31] Jia T.,Zheng Z.,Hou L..et al. Rational design and synergistic optimization of 2D COF nanofiltration membranes: A review J. Environ. Chem. Eng. 2025 13 120507

[32] Patil P. D.,Gargate N.,Tiwari M. S.,Nadar S. S.. Two-dimensional metal-organic frameworks (2D-MOFs) as a carrier for enzyme immobilization: A review on design and bio-applications Int. J. Biol. Macromol. 2025 291 138984

[33] Abdelnasser E.,Ramadan A. E. M.,Ifthikar J..et al. Opportunities of covalent organic frameworks (COFs) as a promising antibacterial agent J. Mol. Struct. 2026 1353 144777

[34] Li R.,Sun F.,Liu Z.,Shi Y.,He S.,Chen J.. Research progress and prospect of covalent organic frameworks (COFs) and composites: From synthesis to application in water contaminants J. Environ. Chem. Eng. 2024 12 113944

[35] Dong X.,Fan M.,Zhao L.,Wang K.,Hu Z.,Liu X.. Recent advances in MOFs based hydrogels: From interactions, synthesis, and functionalization to food applications Trends Food Sci. Technol. 2025 166 105415

[36] Li H.,Eddaoudi M.,O'keeffe M.,Yaghi O. M.. Design and synthesis of an exceptionally stable and highly porous metal-organic framework Nature 1999 402 276 9

[37] Xiong S.,Cui X.,Guo J..et al. Triphenylamine-based covalent organic framework nanospheres: Solvothermal synthesis and electrochromic properties J. Electroanal. Chem. 2023 942 117563

[38] Wang X.,Ma Y.,Ru J..et al. One-step solvent thermal synthesis of 3D networked MOF composites for preparation of an ultrasensitive chemosensor for hydroquinone and catechol Microchim. Acta 2024 191 274

[39] Wu Q.,Wang Y.,Wang L..et al. A portable electrochemical biosensor based on an amino-modified ionic metal-organic framework for the one-site detection of multiple organophosphorus pesticides ACS Appl. Mater. Interfaces 2024 acsami.4c13087

[40] Li W.,Zhang X.,Zhang C..et al. Exploring the corrosion resistance of epoxy coated steel by integrating mechanochemical synthesized 2D covalent organic framework Prog. Org. Coat. 2021 157 106299

[41] Wang Z.,Xie S.,Zhang W..et al. Mechanochemical synthesis ionic covalent organic frameworks/cotton composites for pipette tip solid-phase extraction of domoic acid in seafood Talanta 2024 269 125485

[42] Zhu Z.,Zheng Q.. Investigation of cryo-adsorption hydrogen storage capacity of rapidly synthesized MOF-5 by mechanochemical method Int. J. Hydrogen Energy 2023 48 5166 74

[43] Ji W.,Guo Y.,Xie H.,Wang X.,Jiang X.,Guo D.. Rapid microwave synthesis of dioxin-linked covalent organic framework for efficient micro-extraction of perfluorinated alkyl substances from water J. Hazard. Mater. 2020 397 122793

[44] Mahmoud M. M.. Microwave-assisted fast synthesis of MOF-801 Next Mater. 2025 6 100316

[45] Liu H.,Zhao Y.,Zhou C.,Mu B.,Chen L.. Microwave-assisted synthesis of Zr-based metal-organic framework (Zr-fum-fcu-MOF) for gas adsorption separation Chem. Phys. Lett. 2021 780 138906

[46] Li W.,Wu C.,Zhang Y.,Guo H.,Zhao Z.,Chen M.. Microwave-assisted solvothermal synthesis of cube-shaped MOF-COF composites for copper detection and capture Microchem. J. 2023 191 108925

[47] Maschita J.,Banerjee T.,Savasci G.,Haase F.,Ochsenfeld C.,Lotsch B. V.. Ionothermal synthesis of imide-linked covalent organic frameworks Angew. Chem. Int. Ed. 2020 59 15750 8

[48] Huang Z.,Zhang L.,Cao P.,Wang N.,Lin M.. Electrochemical sensing of dopamine using a Ni-based metal-organic framework modified electrode Ionics 2021 27 1339 45

[49] Kuchekar S.,Gaikwad S.,Han S.. Novel ionothermal synthesis of PZ-MIL-101 (Cr) at low temperature for CO₂ and VOCs adsorption J. Environ. Chem. Eng. 2025 13 116884

[50] Liu Y.,Zhang Y.,Zhu X.,Luan J.,Lan Y.,Li W.. Fabrication of a novel 3D cadmium-organic framework doped with europium as multifunctional fluorescence probes for enhancing detectability J. Solid State Chem. 2024 337 124814

[51] Wei X.,Bi M.,Lou Q.,Di D.,Liu B.,Pei D.. Fast and facile sonochemical fabrication of covalent organic frameworks in water for the adsorption of flavonoids: adsorption behaviors and mechanisms Colloid Surface A 2024 702 134731

[52] Vaitsis C.,Kanellou E.,Pandis P. K..et al. Sonochemical synthesis of zinc adipate metal-organic framework (MOF) for the electrochemical reduction of CO₂: MOF and circular economy potential Sustainable Chem. Pharm. 2022 29 100786

[53] Yu K.,Lee Y.,Seo J. Y.,Baek K.,Chung Y.,Ahn W.. Sonochemical synthesis of Zr-based porphyrinic MOF-525 and MOF-545: Enhancement in catalytic and adsorption properties Microporous Mesoporous Mater. 2021 316 110985

[54] Xie C.,Li H.,Niu B.,Guo H.,Lin X.. Comparison of ultrasonic vs mechanochemistry methods for fabrication of mixed-ligand Zn-based MOFs for electrochemical determination of luteolin J. Alloys Compd. 2024 989 174363

[55] Qing Q.,Luo J.,Liu S..et al. General synthesis of covalent organic frameworks under ambient condition within minutes via microplasma electrochemistry approach Nat. Commun. 2025 16 2571 PMC11910557

[56] Asghar A.,Iqbal N.,Noor T.,Kariuki B. M.,Kidwell L.,Easun T. L.. Efficient electrochemical synthesis of a manganese-based metal-organic framework for H₂ and CO₂ uptake Green Chem. 2021 23 1220 7

[57] Zhang Y.,Li N.,Xu Y..et al. An ultra-sensitive electrochemical aptasensor based on Co-MOF/ZIF-8 nano-thin-film by the in-situ electrochemical synthesis for simultaneous detection of multiple biomarkers of breast cancer Microchem. J. 2023 187 108316

[58] Vehrenberg J.,Vepsäläinen M.,Macedo D. S.,Rubio-Martinez M.,Webster N. A.,Wessling M.. Steady-state electrochemical synthesis of HKUST-1 with polarity reversal Microporous Mesoporous Mater. 2020 303 110218

[59] Ben H.,Du W.,Zhao J..et al. Ionic covalent organic frameworks: From synthetic strategies to advanced electro-, photo-, and thermo- energy functionalities Coord. Chem. Rev. 2024 517 216003

[60] Lalchawimawia B.,Sil A.,Banerjee T..et al. Metal-organic framework-pesticide interactions in water: Present and future perspectives on monitoring, remediation and molecular simulation Coord. Chem. Rev. 2023 490 215214

[61] Akmal M.,Iqbal M. A.,Mawat T. H..et al. Synthesis of metal organic frameworks (MOFs) mechanochemically Inorg. Chem. Commun. 2025 175 114105

[62] Sud D.,Kaur G.. A comprehensive review on synthetic approaches for metal-organic frameworks: From traditional solvothermal to greener protocols Polyhedron 2021 193 114897

[63] Gedye R.,Smith F.,Westaway K..et al. The use of microwave ovens for rapid organic synthesis Tetrahedron Lett. 1986 27 279 82

[64] Gaber A.,Bilge S.,Donar Y. O.,Özoylumlu B.,Kara Z.,Sınağ A.. A first comprehensive review of ionothermal carbon-based supercapacitors J. Power Sources 2025 653 237760

[65] Wang L.,Du H.,Wang X..et al. A critical review of COFs-based photocatalysis for environmental remediation Environ. Res. 2025 272 121166

[66] Tiong T.,Chu J. K.,Tan K. W.. Advancements in acoustic cavitation modelling: progress, challenges, and future directions in sonochemical reactor design Ultrason. Sonochem. 2025 112 107163 PMC11650317

[67] Jajko-Liberka G.,Anagha M.,Chytrosz-Wróbel P..et al. Sonochemical synthesis of nanoparticles from bioactive compounds: advances, challenges, and future perspectives Ultrason. Sonochem. 2025 121 107559 PMC12481127

[68] Guniyangodage Dona R. L.,Rathuwadu N. P.,Koswattage K. R.. Electrochemical synthesis methods for polyaniline nanocomposites: Review Eur. Polym. J. 2025 241 114374

[69] Fenniche F.,Khane Y.,Henni A.,Aouf D.,Elhak Djafri D.. Synthesis and characterization of PANI nanofibers high-performance thin films via electrochemical methods Results Chem. 2022 4 100596

[70] Khaleque M. A.,Aly Saad Aly M.,Khan M. Z. H.. Chemical and electrochemical synthesis of doped conducting polymers and their application in supercapacitors: An overview Chem. Eng. J. 2025 507 160444

[71] Jia M.,Zhang W.,Cai X..et al. Re-understanding the galvanostatic intermittent titration technique: pitfalls in evaluation of diffusion coefficients and rational suggestions J. Power Sources 2022 543 231843

[72] Wang X.,Jiang M.,Yang P..et al. Recent advances in pulsed electrochemical techniques: synthesis of electrode materials and electrocatalytic reactions Surf. Interf. 2024 50 104519

[73] Turan R.,Bilgen E.,Koca A.. Electrode modifications with electrophoretic deposition methods for water electrolyzers Int. J. Hydrogen Energy 2024 81 675 706

[74] Fan T.,Yan Z.,Huang W..et al. A comprehensive review of contents, toxic effects, metabolisms, and environmental behaviors of brominated and organophosphorus flame retardants J. Hazard. Mater. 2025 496 139428

[75] Sagar V.,Kukkar D.. Facile adsorption of organophosphate pesticides over HKUST-1 MOFs Environ. Monit. Assess. 2023 195 1056

[76] Yang C.,Wang J.,Yan W.,Xia Y.. Facile synthesis disposable MOF membrane filter: Growth of NH2-MIL-125 (Ti) on filter paper for fast removal of organophosphorus pesticides in aqueous solution and vegetables Food Chem. 2022 389 133056

[77] Yang Q.,Wang J.,Zhang W..et al. Interface engineering of metal organic framework on graphene oxide with enhanced adsorption capacity for organophosphorus pesticide Chem. Eng. J. 2017 313 19 26

[78] Zhao Y.,Qin K.,Zhou Y.,Liu W.,Gao Z.,Peng Y.. Hierarchically porous Cu-MOF fiber membrane enables instantaneous and continuous removal of organophosphorus pesticides in water J. Environ. Chem. Eng. 2025 13 115877

[79] Rasheed T.,Anwar M. T.,Ahmad R..et al. Tailored covalent organic framework-based heterostructures for integrated electrochemical water splitting and reduction reactions: Interfacial design and charge transfer optimization J. Alloys Compd. 2025 1041 183889

[80] Rahsepar F. R.,Farajzadeh M.,Ansari F.,Shabani A.. A comprehensive review of engineering g-C₃N₄-based hybrid electrocatalysts via integration of carbon materials and MOF-derived nanostructures for OER, HER, and ORR applications Fuel 2026 406 137180

[81] Li F.,Liu R.,Dubovyk V.,Ran Q.,Zhao H.,Komarneni S.. Rapid determination of methyl parathion in vegetables using electrochemical sensor fabricated from biomass-derived and β-cyclodextrin functionalized porous carbon spheres Food Chem. 2022 384 132643

[82] Huang P.,Wu W.,Li M..et al. Metal-organic framework-based nanoarchitectonics: a promising material platform for electrochemical detection of organophosphorus pesticides Coord. Chem. Rev. 2024 501 215534

[83] Qi P.,Wang J.,Li H..et al. Fluffy ball-like magnetic covalent organic frameworks for adsorption and removal of organothiophosphate pesticides Sci. Total Environ. 2022 840 156529

[84] Zhang X.,Hao N.,Liu S..et al. Construction of phosphatase-like COF-OMe@Valine-CeO₂ nanozymes for ultrasensitive electrochemical detection of organophosphorus pesticides Sensor. Actuat B-Chem. 2024 417 136068

[85] Gao N.,Tan R.,Cai Z.,Zhao H.,Chang G.,He Y.. A novel electrochemical sensor via Zr-based metal organic framework-graphene for pesticide detection J. Mater. Sci. 2021 56 19060 74

[86] Cao Y.,Wang L.,Shen C.,Wang C.,Hu X.,Wang G.. An electrochemical sensor on the hierarchically porous Cu-BTC MOF platform for glyphosate determination Sensor. Actuat B-Chem. 2019 283 487 94

[87] Patel R.,Gupta R.,Kushwaha H. S.. Non-enzymatic electrochemical sensing of glyphosate pesticide using nickel-based metal-organic framework Electrocatalysis 2025 16 404 13

[88] Dey B.,Ahmad M. W.,Syed A.,Bahkali A. H.,Verma M.,Choudhury A.. Iron metal organic framework decorated carbon nanofiber-based electrode for electrochemical sensing platform of chlorpyrifos in fruits and vegetables Mater. Sci. Semicond. Process. 2024 181 108669

[89] Yassin J. M.,Taddesse A. M.,Tsegaye A. A.,Sánchez-Sánchez M.. CdS/g-C₃N₄/Sm-BDC MOF nanocomposite modified glassy carbon electrodes as a highly sensitive electrochemical sensor for malathion Appl. Surf. Sci. 2024 648 158973

[90] Janjani P.,Bhardwaj U.,Gupta R.,Singh Kushwaha H.. Bimetallic Mn/Fe MOF modified screen-printed electrodes for non-enzymatic electrochemical sensing of organophosphate Anal. Chim. Acta 2022 1202 339676

[91] Abedeen M. Z.,Laddha H.,Sharma M.,Gupta R.,Kushwaha H. S.. Non-enzyme picomolar sensing of acephate by modified glassy carbon electrode using bimetallic Zn-Cu metal-organic framework J. Electroanal. Chem. 2023 948 117810

[92] Sankhla L.,Abedeen M. Z.,Gupta R.,Kushwaha H. S.. Screen-printed bimetallic cobalt-manganese metal-organic framework electrodes for electrochemical detection of dichlorvos J. Electrochem. Soc. 2024 171 066505

[93] Zhu X.,Li B.,Yang J..et al. Effective adsorption and enhanced removal of organophosphorus pesticides from aqueous solution by Zr-based MOFs of UiO-67 ACS Appl. Mater. Interfaces 2014 7 223 31

[94] Gokila N.,Haldorai Y.,Saravanan P.,Rajendra Kumar R. T.. Non-enzymatic electrochemical impedance sensor for selective detection of electro-inactive organophosphate pesticides using Zr-MOF/ZrO₂/MWCNT ternary composite Environ. Res. 2024 251 118648

[95] Han J.,Li F.,Zhao M..et al. Ultrasensitive electrochemical sensing platform based on Zr-based MOF embellished single-wall carbon nanotube networks for trace analysis of methyl parathion Microchem. J. 2024 200 110323

[96] Guo M.,Li F.,Ran Q..et al. Facile fabrication of Zr-based metal-organic framework/Ketjen black-carbon nanotubes composite sensor for highly sensitive detection of methyl parathion Microchem. J. 2023 190 108709

[97] Khoshsafar H.,Karimian N.,Nguyen T. A..et al. Enzymeless voltammetric sensor for simultaneous determination of parathion and paraoxon based on Nd-based metal-organic framework Chemosphere 2022 292 133440

[98] Sheals J.,Persson P.,Hedman B.. IR and EXAFS Spectroscopic studies of glyphosate protonation and copper(II) complexes of glyphosate in aqueous solution Inorg. Chem. 2001 40 4302 9

[99] Zhang C.,Han M.,Yu L.,Qu L.,Li Z.. Fabrication an electrochemical sensor based on composite of Cu-TCPP nanosheets and PSS functionalized graphene for simultaneous and sensitive determination of dihydroxybenzene isomers J. Electroanal. Chem. 2021 890 115232

[100] Jiang R.,Pang Y.,Yang Q.,Wan C.,Shen X.. Copper porphyrin metal-organic framework modified carbon paper for electrochemical sensing of glyphosate Sensor. Actuat B-Chem. 2022 358 131492

[101] Dey B.,Ahmad M. W.,Kim B. H..et al. Manganese cobalt-MOF@carbon nanofiber-based non-enzymatic histamine sensor for the determination of food freshness Anal. Bioanal. Chem. 2023 415 3487 501

[102] Dey B.,Kushwaha K. S.,Choudhury A..et al. Novel non-enzymatic electrochemical sensing platform based on copper metal organic frameworks for detection of glyphosate herbicide in vegetables extract Microchem. J. 2025 208 112407

[103] Biswas S.,Naskar H.,Pradhan S.,Wang Y.,Bandyopadhyay R.,Pramanik P.. Simultaneous voltammetric determination of Adrenaline and Tyrosine in real samples by neodymium oxide nanoparticles grafted graphene Talanta 2020 206 120176

[104] Mulik B. B.,Munde A. V.,Dighole R. P.,Sathe B. R.. Electrochemical determination of semicarbazide on cobalt oxide nanoparticles: implication towards environmental monitoring J. Environ. Chem. Eng. 2021 93 259 66

[105] Narayanan M.,Singh Chauhan N. P.,Perumal P.. A highly efficient metal oxide incorporated metal organic framework [Nd₂O₃-MIL(Fe)-88A] for the electrochemical detection of dichlorvos RSC Adv. 2023 13 5565 75 PMC9926162

[106] Tao L.,Liu X.,Tan H.,Song J.,Wei J.,Zhu C.. Reliable ratiometric electrochemical sensor for methyl parathion detection in vegetables based on Nile blue A-functionalized Ce-MOF/carbon nanohorns composite Food Chem. 2026 508 148343

[107] Guan H.,Wang N.,Feng X.,Bian S.,Li W.,Chen Y.. FeMn bimetallic MOF directly applicable as an efficient electrocatalyst for overall water splitting Colloid. Surface A 2021 624 126596

[108] Sivasubramaniyan S. M.,Suresh I.,Balasubramanian S.,Nesakumar N.,Rayappan J. B. B.,Kulandaisamy A. J.. Electrochemical detection of profenofos in water using a UiO-67 metal organic framework with graphene oxide composite Anal. Methods 2025 17 4190 205

[109] Janjani P.,Bhardwaj U.,Agarwal M.,Gupta R.,Kushwaha H. S.. MIL-88B(Fe) MOF modified screen-printed electrodes for non-enzymatic electrochemical sensing of malathion Environ. Technol. 2023 45 2649 59

[110] Zhao W.,Lu J.,Chen H..et al. Advance in organophosphorus pesticides detection technology based on acetylcholinesterase inhibition Process Saf. Environ. Prot. 2025 203 107846

[111] Zhang Q.,Yu J.,Wei Y..et al. Advances in acetylcholinesterase-based biosensing technologies for organophosphorus pesticide detection: a comprehensive review (2020-2024) Food Chem. 2025 496 146769

[112] Song Y.,Chen J.,Sun M..et al. A simple electrochemical biosensor based on AuNPs/MPS/Au electrode sensing layer for monitoring carbamate pesticides in real samples J. Hazard. Mater. 2016 304 103 9

[113] Wang X.,Yang S.,Shan J.,Bai X.. Novel electrochemical acetylcholinesterase biosensor based on core-shell covalent organic framework@multi-walled carbon nanotubes (COF@MWCNTs) composite for detection of malathion Int. J. Electrochem. Sci. 2022 17 220543

[114] Yang K.,Zhao H.,Li N..et al. Facile synthesis of novel porphyrin-based covalent organic frameworks integrated with Au nanoparticles for highly sensitive detection of organophosphorus pesticide residues Microchem. J. 2024 203 110945

[115] Mahmoudi E.,Fakhri H.,Hajian A.,Afkhami A.,Bagheri H.. High-performance electrochemical enzyme sensor for organophosphate pesticide detection using modified metal-organic framework sensing platforms Bioelectrochemistry 2019 130 107348

[116] Hosseini M.,Sadat Sabet F.,Khabbaz H.,Aghazadeh M.,Mizani F.,Ganjali M. R.. Enhancement of the peroxidase-like activity of cerium-doped ferrite nanoparticles for colorimetric detection of H₂O₂ and glucose Anal. Methods 2017 9 3519 24

[117] Liu F.,Liang Z.,Zhang Y..et al. Evaluation of the potential application of RAPA-based delivery: Structural evolution and biocompatibility of monodispersed nano-ZIF-8@RAPA Mater. Today Commun. 2025 47 113163

[118] Wen L.,Wang N.,Liu Z..et al. Acetylcholinesterase immobilization on ZIF-8/graphene composite engenders high sensitivity electrochemical sensing for organophosphorus pesticides Chemosensors 2022 10 418

[119] Xue Y.,Gao R.,Lin S.,Zhong Q.,Zhang Q.,Hong J.. Regulating the interface electron distribution of iron-based MOFs through ligand functionalization enables efficient peroxymonosulfate utilization and catalytic performance J. Colloid Interface Sci. 2024 663 358 68

[120] Liu Y.,Zhou M.,Jin C..et al. Preparation of a sensor based on biomass porous carbon/covalent-organic frame composites for pesticide residues detection Front. Chem. 2020 8 643 PMC7485226

[121] Chansi, .; R., P. R.; Mukherjee, I.; Basu, T.; Bharadwaj, L. M. Metal organic framework steered electrosynthesis of anisotropic gold nanorods for specific sensing of organophosphate pesticides in vegetables collected from the field Nanoscale 2020 12 21719 33

[122] Wen S.,Zhang H.,Yu S.,Ma J.,Zhu J.,Zhou Y.. Complementary homogeneous electrochemical and photothermal dual-modal sensor for highly sensitive detection of organophosphorus pesticides via stimuli-responsive COF/methylene blue@MnO₂ composite Anal. Chem. 2023 95 14914 24

[123] Zhao F.,Liu Y.,Lan J.. One-step electrosynthesis of Cu-Hemin MOFs/CNTs for the dual determination of glyphosate Microchim. Acta 2024 191 564

[124] Liu Y.,Wang L.,Li H..et al. Rigorous recognition mode analysis of molecularly imprinted polymers - rational design, challenges, and opportunities Prog. Polym. Sci. 2024 150 101790

[125] Zhong Y.,Li Z.,Zhang A..et al. A molecularly imprinted electrochemical sensor MIP/Cu-MOF/rGO/AuNPs/GCE for highly sensitive detection of electroneutral organophosphorus pesticide residues Microchim. Acta 2024 191 338

[126] Ma X.,Kang J.,Wu Y..et al. A bifunctional polycentric-affinity MOF/MXene heterojunction-based molecularly imprinted photoelectrochemical organophosphorus-sensing platform Chem. Eng. J. 2023 469 143888

[127] Yu L.,Chen X.,Yuan M..et al. MIPs and aptamer-based dual-recognition electrochemical sensor utilizing PtAuNPs functionalized Kagome COFs for ultrasensitive chlorpyrifos detection J. Alloys Compd. 2025 1041 183776

[128] Fan Y.,Li J.,Amin K..et al. Advances in aptamers, and application of mycotoxins detection: a review Food Res. Int. 2023 170 113022

[129] Dong J.,Wang G.,Geng L..et al. Electrochemical aptamer sensor based on bimetallic CuZr-MOF and AuNPs for ultrasensitive detection of organophosphorus pesticides in vegetables J. Food Compos. Anal. 2025 144 107761

[130] Yiwei X.,Xupeng J.,Sennan Y..et al. An aptasensor with colorimetric and electrochemical dual-outputs for malathion detection utilizing peroxidase-like activity of Fe-MOF Food Chemistry: X 2024 24 101835 PMC11437954

[131] Long Y.,Bao L.,Peng Y.,Zhang Z.,Pang D.. Self-co-reactant and ion-annihilation electrogenerated chemiluminescence of carbon nanodots Carbon 2018 129 168 74

[132] Han D.,Yang K.,Sun S.,Wen J.. Signal amplification strategies in electrochemiluminescence biosensors Chem. Eng. J. 2023 476 146688

[133] Zhang W.,Wu J.,Shi W..et al. New function of metal-organic framework: structurally ordered metal promoter Adv. Mater. 2023 35 2303216

[134] Gu C.,Ji S.,Chen Z..et al. Enrichment-catalytic synergistically enhanced electrochemiluminescence sensors based on IRMOF-3/CdTe for ultrasensitive detection of organophosphorus pesticides Biosens. Bioelectron. 2025 279 117398

[135] Shen Z.,Xu R.,Wang G..et al. Self-luminescent dual-ligand metal-organic framework based electrochemiluminescence probes for organophosphorus pesticides determination Food Chem. 2025 478 143679