The application of a herpes simplex virus Type I vector for transgenic therapy

Abstract

The key to successful gene therapy is to effectively transfer genes to target cells and control the effective expression of genes to avoid expression in non-target tissues. At present, there are two common methods of gene therapy: non-replicating viruses and viral vectors. The use of non-replicating viruses as vectors often limits the efficiency of gene transfer and is unsatisfactory for clinical application. In contrast, replicative viral vectors can deliver genes from a small number of cells to neighboring cells, significantly improve the efficiency of gene delivery, and stably and persistently express exogenous genes. As a result, the investigation and application of viral vectors are recommended. Herpes simplex virus Type I-derived vectors have gradually become important biological treatments due to their wide host range, integration of long fragments of exogenous DNA, neurotropism, and various animal models.

Keywords

Herpes simplex virus Type I / Gene therapy / Vectors / Transgenic technology