ABO blood type and cancer susceptibility: Unraveling the complex relationship

Abstract

Different human diseases have been associated with specific blood groups. Numerous studies have promulgated their findings regarding the probable onset of various cancers based on the type of ABO blood group. However, the findings have been conflicting. This review primarily aims to summarize research findings from around the world to investigate the relationship between the risk of cancer occurrence and ABO blood group. Google Scholar, PubMed, Research4Life, and Web of Science were searched to identify relevant papers published before January 2023. Research papers related to common types of cancers were adequately and critically studied to determine the link between ABO blood groups and the risk of developing cancers. The results were ambiguous, as the findings were inconsistent regarding the relationship between ABO blood groups and cancer development. Therefore, more comprehensive research is needed to validate this relationship. This mini-systematic review emphasizes the need for additional thorough investigations to establish a clear correlation because of the inconsistent results.

Keywords

ABO / blood group / cancer risk / relationship

Funding

None.

Conflict of interest

The authors declare no conflict of interest.

References

[1] Di Meo S, Iossa S, Venditti P. Skeletal muscle insulin resistance: Role of mitochondria and other ROS sources. J Endocrinol. 2017; 233(1):R15-R42. doi: 10.1530/JOE-16-0598

[2] Liumbruno GM, Franchini M. Hemostasis, cancer, and ABO blood group: The most recent evidence of association. J Thromb Thrombolysis. 2014; 38(2):160-166. doi: 10.1007/s11239-013-1027-4

[3] Siransy LK, Nanga ZY, Zaba FS, Tufa NY, Dasse SR. ABO/ Rh blood groups and risk of HIV infection and hepatitis B among blood donors of Abidjan, Côte D’ivoire. Eur J Microbiol Immunol. 2015; 5(3):205-209. doi: 10.1556/1886.2015.00029

[4] Beauchemin N, Arabzadeh A. Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis. Cancer Metastasis Rev. 2013; 32(3-4):643-671. doi: 10.1007/s10555-013-9444-6

[5] Pasko BE, Abbott D, Bocsi GT, Draper NL. ABO blood groups are not associated with COVID-19 disease incidence and severity when correcting for ethnicity differences in blood type. Am J Clin Pathol. 2022; 158(2):249-253. doi: 10.1093/ajcp/aqac036

[6] Ewald DR, Sumner SCJ. Blood type biochemistry and human disease. Wiley Interdiscip Rev Syst Biol Med. 2016; 8(6):517-535. doi: 10.1002/wsbm.1355

[7] Ogasawara K, Sano R, Kominato Y. Review of ABO expression and variations based on transcriptional regulation of the ABO blood group gene. Transfus Med Hemother. 2024; 51(4):210-224. doi: 10.1159/000536556

[8] Franchini M, Liumbruno GM, Lippi G. The prognostic value of ABO blood group in cancer patients. Blood Transfus. 2016; 14(5):434-440. doi: 10.2450/2015.0164-15

[9] Aird I, Bentall HH, Roberts JA. A relationship between cancer of stomach and the ABO blood groups. Br Med J. 1953; 1(4814):799-801. doi:10.1136/bmj.1.4814.799

[10] Shvartsur A, Bonavida B. Trop2 and its overexpression in cancers: Regulation and clinical/therapeutic implications. Genes Cancer. 2015; 6(3-4):84-105. doi: 10.18632/genesandcancer.40

[11] Reid ME, Bird GW. Associations between human red cell blood group antigens and disease. Transfus Med Rev. 1990; 4(1):47-55. doi: 10.1016/s0887-7963(90)70247-7

[12] Benvenuto M, Focaccetti C, Izzi V, Masuelli L, Modesti A, Bei R. Tumor antigens heterogeneity and immune response-targeting neoantigens in breast cancer. Semin Cancer Biol. 2021; 72:65-75. doi: 10.1016/j.semcancer.2019.10.023

[13] Hu B, Zhang H, Zhang Y, Jin Y. A nomogram based on biparametric magnetic resonance imaging for detection of clinically significant prostate cancer in biopsy-naïve patients. Cancer Imaging. 2023; 23(1):82. doi: 10.1186/s40644-023-00606-2

[14] Müller V, Hein A, Hartkopf AD, et al. Occurrence and characteristics of patients with de novo advanced breast cancer according to patient and tumor characteristics - A retrospective analysis of a real world registry. Eur J Cancer. 2022; 172:13-21. doi: 10.1016/j.ejca.2022.05.015

[15] Garratty G. Blood groups and disease: A historical perspective. Transfus Med Rev. 2000; 14(4):291-301. doi: 10.1053/tmrv.2000.16228

[16] Ghafel N. Association of the blood groups with mostly public diseases. Kufa Jour Nurs Sci. 2021; 11(1):1-17. doi: 10.36321/kjns.vi20211.471

[17] Rummel SK, Ellsworth RE. The role of the histoblood ABO group in cancer. Future Sci OA. 2016; 2(2):FSO107. doi: 10.4155/fsoa-2015-0012

[18] Ah-Moye D, Davies C, Goody J, Hayward P, Frewin R. Introduction to haematology and transfusion science. In: Clinical Biochemistry: Metabolic and Clinical Aspects. United Kingdom: Churchill Livingstone; 2014. p. 497-514. doi:10.1016/B978-0-7020-5140-1.00026-2

[19] Franchini M, Liumbruno GM. ABO blood group: Old dogma, new perspectives. Clin Chem Lab Med. 2013; 51(8):1545-1553. doi: 10.1515/cclm-2013-0168

[20] Franchini M, Crestani S, Frattini F, Sissa C, Bonfanti C. ABO blood group and von Willebrand factor: Biological implications. Clin Chem Lab Med. 2014; 52(9):1273-1276. doi: 10.1515/cclm-2014-0564

[21] Eastlund T. The histo-blood group ABO system and tissue transplantation. Transfusion. 1998; 38(10):975-988. doi: 10.1046/j.1537-2995.1998.381098440863.x

[22] Yamamoto F, Cid E, Yamamoto M, Blancher A. ABO research in the modern era of genomics. Transfus Med Rev. 2012; 26(2):103-118. doi: 10.1016/j.tmrv.2011.08.002

[23] Strauchen JA, Bergman SM, Hanson TA. Expression of A and B tissue isoantigens in benign and malignant lesions of the breast. Cancer. 1980; 45(8):2149-2155. doi: 10.1002/1097-0142(19800415)45:8<2149:aid-cncr2820450823>3.0.co;2-7

[24] Chen PH, Bossuyt V, Reisenbichler E. Expression of lymphoid enhancer-binding factor 1 in breast fibroepithelial lesions. Hum Pathol. 2021; 108:68-75. doi: 10.1016/j.humpath.2020.11.009

[25] Li D, Wang M, Qi J, et al. Human group A rotavirus P [²⁵VP8* specifically binds to A-type histo-blood group antigen. Virology. 2021; 555:56-63. doi: 10.1016/j.virol.2020.12.016

[26] Garratty G, Glynn SA, McEntire R, Retrovirus epidemiology donor study. ABO and Rh(D) phenotype frequencies of different racial/ethnic groups in the United States. Transfusion. 2004; 44(5):703-706. doi: 10.1111/j.1537-2995.2004.03338.x

[27] Castillo B, Dasgupta A, Klein K, Tint H, Wahed A. Transfusion Medicine for Pathologists: A Comprehensive Review for Board Preparation, Certification, and Clinical Practice. United States: Academic Press; 2018. doi:10.1016/B978-0-12-814313-1.00013-7

[28] Hakomori S. Tumor-associated carbohydrate antigens defining tumor malignancy: Basis for development of anti-cancer vaccines. Adv Exp Med Biol. 2001;491:369-402. doi: 10.1007/978-1-4615-1267-7_24

[29] Hakomori S. Antigen structure and genetic basis of histo-blood groups A, B and O: Their changes associated with human cancer. Biochim Biophys Acta. 1999; 1473(1):247-266. doi: 10.1016/s0304-4165(99)00183-x

[30] Roseman S.Reflections on glycobiology. J Biol Chem. 2001; 276(45):41527-41542. doi: 10.1074/jbc.R100053200

[31] Zhang S, Zhang HS, Cordon-Cardo C, et al. Selection of tumor antigens as targets for immune attack using immunohistochemistry: II. Blood group-related antigens. Int J Cancer. 1997; 73(1):50-56. doi: 10.1002/(sici)1097-0215(19970926)73:1<50:aid-ijc9>3.0.co;2-0

[32] Capuzzo E, Bonfanti C, Frattini F, et al. The relationship between ABO blood group and cardiovascular disease: Results from the Cardiorisk program. Ann Transl Med. 2016; 4(10):189. doi: 10.21037/atm.2016.03.58

[33] Franchini M, Frattini F, Crestani S, Bonfanti C, Lippi G. von Willebrand factor and cancer: A renewed interest. Thromb Res. 2013; 131(4):290-292. doi: 10.1016/j.thromres.2013.01.015

[34] Jenkins PV, O’Donnell JS. ABO blood group determines plasma von Willebrand factor levels: A biologic function after all? Transfusion. 2006; 46(10):1836-1844. doi: 10.1111/j.1537-2995.2006.00975.x

[35] Grivennikov SI, Greten FR, Karin M.Immunity, inflammation, and cancer. Cell. 2010; 140(6):883-899. doi: 10.1016/j.cell.2010.01.025

[36] Melzer D, Perry JRB, Hernandez D, et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet. 2008; 4(5):e1000072. doi: 10.1371/journal.pgen.1000072

[37] Greenwell P. Blood group antigens: Molecules seeking a function? Glycoconj J. 1997; 14(2):159-173. doi: 10.1023/a:1018581503164

[38] Kaffenberger SD, Morgan TM, Stratton KL, et al. ABO blood group is a predictor of survival in patients undergoing surgery for renal cell carcinoma. BJU Int. 2012; 110(11 Pt B):E641-E646. doi: 10.1111/j.1464-410X.2012.11366.x

[39] Eibl G, Edderkaoui M. Risk Factors for Pancreatic Cancer: Underlying Mechanisms and Potential Targets. Switzerland: Frontiers Media; 2015. doi: 10.3389/fphys.2014.00490

[40] Neoptolemos JP, Urrutia RA, Abbruzzese J, Büchler MW. Pancreatic Cancer. Germany: Springer Science and Business Media; 2010. doi:10.1007/978-1-4939-7193-0

[41] Bahia D, Satoskar A, Dussurget O. Cell Signaling in Host- Pathogen Interactions: The Host Point of View. Switzerland: Frontiers Media; 2018. doi:10.3389/fimmu.2018.00221

[42] Zusso M, Moro S, Giusti P, Stokes L. Neuroinflammation and Its Resolution: From Molecular Mechanisms to Therapeutic Perspectives. Switzerland: Frontiers Media; 2020. doi:10.3389/fphar.2020.00480

[43] Bronte F, Manu KA, Giunta EF. Reviews in Gastrointestinal Cancers. Switzerland: Frontiers Media; 2023. doi:10.3389/fonc.2023.1252665

[44] Shad KF. Blood Groups: More than Inheritance of Antigenic Substances. Germany: BoD - Books on Demand; 2022. doi: 10.5772/intechopen.94700

[45] Mao Y, Yang W, Qi Q, et al. Blood groups A and AB are associated with increased gastric cancer risk: Evidence from a large genetic study and systematic review. BMC Cancer. 2019; 19(1):164. doi: 10.1186/s12885-019-5355-4

[46] Yu H, Xu N, Li ZK, et al. Association of ABO blood groups and risk of gastric cancer. Scand J Surg. 2020; 109(4):309-313. doi: 10.1177/1457496919863886

[47] Huang JY, Wang R, Gao YT, Yuan JM. ABO blood type and the risk of cancer - Findings from the Shanghai Cohort Study. PLoS One. 2017; 12(9):e0184295. doi: 10.1371/journal.pone.0184295

[48] Liu Y, Chen S, Shen W, Qu X, Li S, Shi Y. Construction and validation of a gastric cancer diagnostic model based on blood groups and tumor markers. J Cancer. 2024; 15(3):729-736. doi: 10.7150/jca.88190

[49] Sun W, Wen CP, Lin J, et al. ABO blood types and cancer risk--a cohort study of 339,432 subjects in Taiwan. Cancer Epidemiol. 2015; 39(2):150-156. doi: 10.1016/j.canep.2014.12.006

[50] Tanaka Y, Kumagi T, Terao T, et al. ABO blood type and the long-term outcomes of pancreatic cancer. Intern Med. 2020; 59(6):761-768. doi: 10.2169/internalmedicine.3748-19

[51] Nakao M, Matsuo K, Hosono S, et al. ABO blood group alleles and the risk of pancreatic cancer in a Japanese population. Cancer Sci. 2011; 102(5):1076-1080. doi: 10.1111/j.1349-7006.2011.01907.x

[52] Greer JB, Yazer MH, Raval JS, Barmada MM, Brand RE, Whitcomb DC. Significant association between ABO blood group and pancreatic cancer. World J Gastroenterol. 2010; 16(44):5588-5591. doi: 10.3748/wjg.v16.i44.5588

[53] Vedie AL, Laouali N, Gelot A, Severi G, Boutron- Ruault MC, Rebours V. Childhood and adulthood passive and active smoking, and the ABO group as risk factors for pancreatic cancer in women. United Eur Gastroenterol J. 2024; 12(4):440-450. doi: 10.1002/ueg2.12487

[54] Engin H, Bilir C, Üstün H, Gökmen A. ABO blood group and risk of pancreatic cancer in a Turkish population in Western Blacksea region. Asian Pac J Cancer Prev. 2012; 13(1):131-133.

[55] Li X, Xu H, Gao P. ABO Blood group and diabetes mellitus influence the risk for pancreatic cancer in a population from China. Med Sci Monit. 2018; 24:9392-9398. doi: 10.12659/MSM.913769

[56] Ateeb Z, Valente R, Pozzi-Mucelli RM, et al. Main pancreatic duct dilation greater than 6 mm is associated with an increased risk of high-grade dysplasia and cancer in IPMN patients. Langenbecks Arch Surg. 2019; 404(1):31-37. doi: 10.1007/s00423-018-1740-8

[57] Gupta A, Saraiya V, Deveaux A, et al. Association of lipid profile biomarkers with breast cancer by molecular subtype: Analysis of the MEND study. Sci Rep. 2022; 12(1):10631. doi: 10.1038/s41598-022-13740-x

[58] Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A.Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6):394-424. doi: 10.3322/caac.21492

[59] Lei S, Zheng R, Zhang S, et al. Global patterns of breast cancer incidence and mortality: A population-based cancer registry data analysis from 2000 to 2020. Cancer Commun. 2021; 41(11):1183-1194. doi: 10.1002/cac2.12207

[60] Saxena S, Chawla VK, Gupta KK, Gaur KL. Association of ABO blood group and breast cancer in Jodhpur. Indian J Physiol Pharmacol. 2015; 59(1):63-68.

[61] Singh K, Kote S, Patthi B, et al. Relative risk of various head and neck cancers among different blood groups: An analytical study. J Clin Diagn Res. 2014; 8(4):ZC25-ZC28. doi: 10.7860/JCDR/2014/7949.4244

[62] Urun Y, Utkan G, Altundag K, et al. ABO and Rh blood groups frequency in women with HER2 positive breast cancer. J BUON. 2012; 17(3):457-460.

[63] Aly R, Yousef A. Association of ABO blood group and risk of breast cancer. J Blood Disord Transfus. 2014; 5(9):1000241. doi: 10.4172/2155-9864.1000241

[64] Flavarjani AH, Hedayatpour B, Bashardoost N, Nourian SM. Study of the association between blood types and breast cancer among Isfahanian women with breast cancer. Adv Biomed Res. 2014;3:43. doi: 10.4103/2277-9175.125749

[65] Meo SA, Suraya F, Jamil B, et al. Association of ABO and Rh blood groups with breast cancer. Saudi J Biol Sci. 2017; 24(7):1609-1613. doi: 10.1016/j.sjbs.2017.01.058

[66] Dede DS, Aksoy S, Dizdar O, et al. Blood ABO groups and risk of breast cancer. Med Oncol. 2010; 27(4):1433. doi: 10.1007/s12032-009-9346-1

[67] Klimant E, Glurich I, Mukesh B, Onitilo AA. Blood type, hormone receptor status, HER2/neu status, and survival in breast cancer: a retrospective study exploring relationships in a phenotypically well-defined cohort. Clin Med Res. 2011; 9(3-4):111-118. doi: 10.3121/cmr.2011.907

[68] Miao SY, Zhou W, Chen L, Wang S, Liu XA. Influence of ABO blood group and Rhesus factor on breast cancer risk: A meta-analysis of 9665 breast cancer patients and 244,768 controls. Asia Pac J Clin Oncol. 2014; 10(2):101-108. doi: 10.1111/ajco.12083

[69] Guleria K, Singh HP, Kaur H, Sambyal V. ABO blood groups in gastrointestinal tract (GIT) and breast carcinoma patients. Anthropologist. 2005; 7(3):189-192. doi: 10.1080/09720073.2005.11890905

[70] Mourali N, Muenz LR, Tabbane F, Belhassen S, Bahi J, Levine PH. Epidemiologic features of rapidly progressing breast cancer in Tunisia. Cancer. 1980; 46(12):2741-2746. doi: 10.1002/1097-0142(19801215)46:12<2741:aid-cncr2820461234>3.0.co;2-w

[71] Gates MA, Wolpin BM, Cramer DW, Hankinson SE, Tworoger SS. ABO blood group and incidence of epithelial ovarian cancer. Int J Cancer. 2011; 128(2):482-486. doi: 10.1002/ijc.25339

[72] Zhang Y, Xu H, Pi S, Tan H, Huang B, Chen Y. The prognostic and immunological role of FKBP1A in an integrated muti-omics cancers analysis, especially lung cancer. J Cancer Res Clin Oncol. 2023;149:16589-16608. doi: 10.1007/s00432-023-05362-1

[73] Yu J, Gao F, Klimberg VS, Margenthaler JA. ABO blood type/Rh factor and the incidence and outcomes for patients with triple-negative breast cancer. Ann Surg Oncol. 2012; 19(10):3159-3164. doi: 10.1245/s10434-012-2533-x

[74] Amini M, Fatah SH, Kalantari M. ABO blood groups and prognosis of breast cancer: A case-control study in Arak/ Iran. Iran J Blood Cancer. 2012; 4(2):61-65.

[75] Majupuria KC, Gupta SR, Gupta LC. The study of ABO blood groups and relationship with cancer breast (a preliminary report). Indian J Cancer. 1966; 3(3):182-183.

[76] Costantini M, Fassio T, Canobbio L, Landucci M, Resasco M, Boccardo F. Role of blood groups as prognostic factors in primary breast cancer. Oncology. 1990; 47(4):308-312. doi: 10.1159/000226839

[77] Holdsworth PJ, Thorogood J, Benson EA, Clayden AD. Blood group as a prognostic indicator in breast cancer. Br Med J. 1985; 290(6469):671-673. doi: 10.1136/bmj.290.6469.671

[78] Stamatakos M, Kontzoglou K, Safioleas P, Safioleas C, Manti C, Safioleas M. Breast cancer incidence in Greek women in relation to ABO blood groups and Rh factor. Int Semin Surg Oncol. 2009;6:14. doi: 10.1186/1477-7800-6-14

[79] Tryggvadottir L, Tulinius H, Robertson JM. Familial and sporadic breast cancer cases in Iceland: A comparison related to ABO blood groups and risk of bilateral breast cancer. Int J Cancer. 1988; 42(4):499-501. doi: 10.1002/ijc.2910420405

[80] Anderson DE, Haas C. Blood type A and familial breast cancer. Cancer. 1984; 54(9):1845-1849. doi: 10.1002/1097-0142(19841101)54:9<1845:aid-cncr2820540913>3.0.co;2-5

[81] Cao X, Wen ZS, Sun YJ, Li Y, Zhang L, Han YJ. Prognostic value of ABO blood group in patients with surgically resected colon cancer. Br J Cancer. 2014; 111(1):174-180. doi: 10.1038/bjc.2014.302

[82] Rashid G, Bhat GA, Rather TB, et al. ABO and Rhesus blood group markers as predictors in colorectal cancer: A prospective observational study. Medicine (Baltimore). 2023; 102(47):e36256. doi: 10.1097/MD.0000000000036256

[83] Jodat H, Jodat J, Khodadadi A, Talaiezadeh A, Joudaki N, Asadirad A. A study of association of ABO and Rh blood group with colorectal cancer in Khuzestan province, Iran. Int J Hematol Oncol Stem Cell Res. 2023; 17(4):275-280. doi: 10.18502/ijhoscr.v17i4.13919

[84] Khalili H, Wolpin BM, Huang ES, et al. ABO blood group and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2011; 20(5):1017-1020. doi: 10.1158/1055-9965.EPI-10-1250

[85] Li B, Tan B, Chen C, Zhao L, Qin L. Association between the ABO blood group and risk of common cancers. J Evid Based Med. 2014; 7(2):79-83. doi: 10.1111/jebm.12098

[86] Zhang WN, Liang WJ, Zhang Y, et al. Molecular characteristics of patients with colorectal signet-ring cell carcinoma with different ABO blood groups. Heliyon. 2024; 10(13):e34220. doi: 10.1016/j.heliyon.2024.e34220

[87] Wei S, Yi T, OuYang Z, Wu J. Association between ABO blood type and type I endometrial cancer: A retrospective study. J Obstet Gynaecol. 2023; 43(1):2153026. doi: 10.1080/01443615.2022.2153026

[88] Bahardoust M, Dehkharghani MZ, Ebrahimi P, et al. Effect of ABO blood group on postoperative overall survival and recurrence-free survival rate in patients with hepatocellular carcinoma after hepatectomy: A multi-center retrospective cohort study. BMC Surg. 2023; 23(1):324. doi: 10.1186/s12893-023-02236-8

[89] Ferlay J, Colombet M, Soerjomataram I, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019; 144(8):1941-1953. doi: 10.1002/ijc.31937

[90] Wang GN, Zhou S, Chen C, et al. O Blood type is associated with unfavorable distant-metastasis-free survival in female patients with nasopharyngeal carcinoma: A retrospective study of 2439 patients from epidemic area. J Cancer. 2019; 10(5):1297-1306. doi: 10.7150/jca.28372

[91] Stakišaitis D, Juknevičienė M, Ulys A, et al. ABO blood group polymorphism has an impact on prostate, kidney and bladder cancer in association with longevity. Oncol Lett. 2018; 16(1):1321-1331. doi: 10.3892/ol.2018.8749

[92] Kvist E, Krogh J, Hjortberg P. Prognostic variables in patients with prostate cancer: Influence of blood group ABO (H), the Rhesus system, age, differentiation, tumour stage and metastases. Int Urol Nephrol. 1992; 24(4):417-423. doi: 10.1007/BF02550636

[93] Markt SC, Shui IM, Unger RH, et al. ABO blood group alleles and prostate cancer risk: Results from the breast and prostate cancer cohort consortium (BPC3). Prostate. 2015; 75(15):1677-1681. doi: 10.1002/pros.23035

[94] Wajsman Z, Saroff J, Murphy GP. Blood group distribution in prostatic cancer patients. J Surg Oncol. 1977; 9(3):289-291. doi: 10.1002/jso.2930090311

[95] Chastonay P, Hurlimann J, Gardiol D. Biological tissue markers in benign and malignant disease of the human prostate. Virchows Arch A Pathol Anat Histopathol. 1986; 410(3):221-229. doi: 10.1007/BF00710828

[96] Ghazizadeh M, Kagawa S, Takigawa H, Kurokawa K, Numoto S. Specific red cell adherence test in benign and malignant lesions of the prostate. Br J Urol. 1983; 55(4):405-407. doi: 10.1111/j.1464-410x.1983.tb03332.x

[97] Abel PD, Marsh C, Henderson D, Leathem A, Powell PH, Williams G. Detection of blood group antigens in frozen sections of prostatic epithelium. Br J Urol. 1987; 59(5):430-435. doi: 10.1111/j.1464-410x.1987.tb04841.x

[98] Kasperzyk JL, Finn SP, Flavin R, et al. Prostate-specific membrane antigen protein expression in tumor tissue and risk of lethal prostate cancer. Cancer Epidemiol Biomarkers Prev. 2013; 22(12):2354-2363. doi: 10.1158/1055-9965.EPI-13-0668

[99] Ohno Y, Ohori M, Nakashima J, et al. Associations between ABO blood groups and biochemical recurrence after radical prostatectomy. Int J Clin Exp Med. 2015; 8(2):2642-2648.

[100] Breimer ME, Mölne J, Nordén G, Rydberg L, Thiel G, Svalander CT. Blood group A and B antigen expression in human kidneys correlated to A1/A2/B, Lewis, and secretor status. Transplantation. 2006; 82(4):479-485. doi: 10.1097/01.tp.0000231697.15817.51

[101] Lee C, You D, Sohn M, et al. Prognostic value of ABO blood group in patients with renal cell carcinoma: Single-institution results from a large cohort. J Cancer Res Clin Oncol. 2015; 141(8):1441-1447. doi: 10.1007/s00432-015-1908-3

[102] De Martino M, Waldert M, Haitel A, Schatzl G, Shariat SF, Klatte T. Evaluation of ABO blood group as a prognostic marker in renal cell carcinoma (RCC). BJU Int. 2014; 113(5b):E62-66. doi: 10.1111/bju.12436

[103] Joh HK, Cho E, Choueiri TK. ABO blood group and risk of renal cell cancer. Cancer Epidemiol. 2012; 36(6):528-532. doi: 10.1016/j.canep.2012.07.001

[104] Abegaz SB. Human ABO Blood Groups and their associations with different diseases. Biomed Res Int. 2021;2021:6629060. doi: 10.1155/2021/6629060

[105] Milas I, Kaštelan Ž, Petrik J, et al. ABO blood type and urinary bladder cancer: Phenotype, genotype, Allelic association with a clinical or histological stage and recurrence rate. Glob Med Genet. 2024; 11(3):233-240. doi: 10.1055/s-0044-1788614

[106] Llopis B, Ruiz JL, Server G, Marty M, Gallego J, Jiménez- Cruz JF. ABO blood groups and bladder carcinoma. Eur Urol. 1990; 17(4):289-292. doi: 10.1159/000464061

[107] Klatte T, Xylinas E, Rieken M, et al. Impact of ABO blood type on outcomes in patients with primary nonmuscle invasive bladder cancer. J Urol. 2014; 191(5):1238-1243. doi: 10.1016/j.juro.2013.11.106

[108] Poole EM, Gates MA, High BA, et al. ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium. Cancer Causes Control. 2012; 23(11):1805-1810. doi: 10.1007/s10552-012-0059-y

[109] Yuzhalin AE, Kutikhin AG. ABO and Rh blood groups in relation to ovarian, endometrial and cervical cancer risk among the population of South-East Siberia. Asian Pac J Cancer Prev. 2012; 13(10):5091-5096. doi: 10.7314/apjcp.2012.13.10.5091

[110] Mitra S, Mondal S, Basu A. The study of ABO blood groups in cancer of the female genital organs and cancer of the breast. Cancer. 1962; 15(1):39-41. doi: 10.1002/1097-0142(196201/02)15:1<39:aid-cncr2820150106>3.0.co;2-x doi: 10.1002/1097-0142(196201/02)15:1<39:aid-cncr28201 50106>3.0.co;2-x

[111] Newell GR, Gordon JE, Monlezun AP, Horwitz JS.ABO blood groups and cancer. J Natl Cancer Inst. 1974; 52(5):1425-1430. doi: 10.1093/jnci/52.5.1425

[112] Tailor HJ, Rajani AD, Hathila RN, Patel PR. Relationship between ABO blood Group and Carcinoma of Cervix in South Gujarat Women. Ann Pathol Lab Med. 2020; 7(3):A107-A110. doi: 10.21276/apalm.2637

[113] Mittal VP. Blood groups and cancer of the cervix uteri. J Obstet Gynaecol India. 1970; 20(2):240-242.

[114] Segi M, Fujisaku S, Kurihara M, Moniwa H. Cancer of cervix uteri and ABO blood groups. Tohoku J Exp Med. 1957; 66(1):50. doi: 10.1620/tjem.66.50

[115] Kaur I, Singh IP, Bhasin MK. Blood groups in relation to carcinoma of cervix uteri. Hum Hered. 1992; 42(5):324-326. doi: 10.1159/000154091

[116] Adelusi B. Haemoglobin genotype, ABO blood groups and carcinoma of the cervix. J Trop Med Hyg. 1977; 80(7):152-154.

[117] Mandato VD, Torricelli F, Mastrofilippo V, et al. ABO/Rh blood group and cervical cancer survival: Results from our own and other studies. J Cancer. 2024; 15(15):4777-4788. doi: 10.7150/jca.95245

[118] Lin K, Qiu F, Chen S, He X, Peng S, Chen H. Lack of association between the distribution of ABO blood groups and nasopharyngeal carcinoma in a population of Southern China. J Cancer Res Ther. 2018; 14(4):785-788. doi: 10.4103/jcrt.JCRT_567_17

[119] Sheng L, Sun X, Zhang L, Su D. ABO blood group and nasopharyngeal carcinoma risk in a population of Southeast China. Int J Cancer. 2013; 133(4):893-897. doi: 10.1002/ijc.28087

[120] Urun Y, Utkan G, Cangir AK, et al. Association of ABO blood group and risk of lung cancer in a multicenter study in Turkey. Asian Pac J Cancer Prev. 2013; 14(5):2801-2803. doi: 10.7314/apjcp.2013.14.5.2801

[121] Unal D, Eroglu C, Kurtul N, Oguz A, Tasdemir A, Kaplan B. ABO blood groups are not associated with treatment response and prognosis in patients with local advanced non- small cell lung cancer. Asian Pac J Cancer Prev. 2013; 14(6):3945-3948. doi: 10.7314/apjcp.2013.14.6.3945

[122] Xie J, Qureshi AA, Li Y, Han J. ABO blood group and incidence of skin cancer. PLoS One. 2010; 5(8):e11972. doi: 10.1371/journal.pone.0011972

[123] Cihan YB, Baykan H, Kavuncuoglu E, et al. Relationships between skin cancers and blood groups--link between non-melanomas and ABO/Rh factors. Asian Pac J Cancer Prev. 2013; 14(7):4199-4203. doi: 10.7314/apjcp.2013.14.7.4199

[124] Edgren G, Hjalgrim H, Rostgaard K, et al. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: A cohort study. Am J Epidemiol. 2010; 172(11):1280-1285. doi: 10.1093/aje/kwq299

[125] Li J, Ma X, Chakravarti D, Shalapour S, DePinho RA. Genetic and biological hallmarks of colorectal cancer. Genes Dev. 2021; 35(11-12):787-820. doi: 10.1101/gad.348226.120

[126] Housset M, Maulard C, Chretien Y, et al. Combined radiation and chemotherapy for invasive transitional-cell carcinoma of the bladder: A prospective study. J Clin Oncol. 1993; 11(11):2150-2157. doi: 10.1200/JCO.1993.11.11.2150

[127] Hanprasertpong J, Jiamset I, Atjimakul T. Prognostic value of ABO blood group in patients with early stage cervical cancer treated with radical hysterectomy with pelvic node dissection. Tumour Biol. 2016; 37(6):7421-7430. doi: 10.1007/s13277-015-4626-1

[128] Sharma SV, Bell DW, Settleman J, Haber DA. Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer. 2007; 7(3):169-181. doi: 10.1038/nrc2088

[129] Yuzhalin AE, Kutikhin AG. Integrative systems of genomic risk markers for cancer and other diseases: Future of predictive medicine. Cancer Manag Res. 2012; 4:131-135. doi: 10.2147/CMAR.S30855