Potential vagus nerve-related adverse events in rotavirus vaccination

Abstract

Vagus nerve-related adverse events (AEs) can be triggered by gastrointestinal infections. This raises the question of whether AE data from live-attenuated virus vaccination can be leveraged to investigate potential vagus nerve involvement. In this study, data from the Vaccine AEs Reporting System were retrospectively analyzed for candidate vagus nerve-related AEs in infants aged 0 and 1. Live-attenuated rotavirus vaccinations were associated with elevated normalized frequencies across all 16 selected vagus nerve-related AEs in both age groups, with the majority showing higher normalized frequencies in infants aged 0 than in those aged 1. These findings suggest that oral, live-attenuated virus vaccination may provide valuable insights into vagus nerve-related AEs. Furthermore, the higher normalized frequencies of AEs observed in infants aged 0 could indicate that the administered dose or minimum infectious units may be excessive for a subset of younger infants.

Keywords

Vagus nerve / Rotavirus / Vomiting / Emesis

Acknowledgments

None.

Funding

None.

Conflict of interest

The author declares no conflicts of interest.

Author contributions

This is a single-authored article.

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Availability of data

The original data supporting this study have been uploaded to the Harvard Dataverse (https://doi.org/10.7910/DVN/PFN1ZR).

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