Metabolic Reprogramming of the Pre-Metastatic Niche: A Sweet Spot for Anti-Tumor Immunity

Xuan Zhang; Xinghua Long

doi:10.1002/mog2.70056

MEDCOMM - Oncology ›› 2026, Vol. 5 ›› Issue (1) :e70056 DOI: 10.1002/mog2.70056

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Metabolic Reprogramming of the Pre-Metastatic Niche: A Sweet Spot for Anti-Tumor Immunity

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Xuan Zhang, Xinghua Long. Metabolic Reprogramming of the Pre-Metastatic Niche: A Sweet Spot for Anti-Tumor Immunity. MEDCOMM - Oncology, 2026, 5(1): e70056 DOI:10.1002/mog2.70056

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References

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[1]	C. Y. Wu, C. X. Huang, X. M. Lao, et al., “Glucose Restriction Shapes Pre-Metastatic Innate Immune Landscapes in the Lung Through Exosomal Trail,” Cell188, no. 20 (2025): 5701–5716.e19.

[2]	W. J. Turbitt, W. Demark-Wahnefried, C. M. Peterson, and L. A. Norian, “Targeting Glucose Metabolism to Enhance Immunotherapy: Emerging Evidence on Intermittent Fasting and Calorie Restriction Mimetics,” Frontiers in Immunology10 (2019): 1402.

[3]	A. Gähler, D. I. Trufa, M. T. Chiriac, et al., “Glucose-Restricted Diet Regulates the Tumor Immune Microenvironment and Prevents Tumor Growth in Lung Adenocarcinoma,” Frontiers in Oncology12 (2022): 873293.

[4]	Y. Liu and X. Cao, “Characteristics and Significance of the Pre-Metastatic Niche,” Cancer Cell30, no. 5 (2016): 668–681.

[5]	X. Tian, P. R. Srinivasan, V. Tajiknia, et al., “Targeting Apoptotic Pathways for Cancer Therapy,” Journal of Clinical Investigation134, no. 14 (2024): e179570.

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2026 The Author(s). MedComm – Oncology published by John Wiley & Sons Australia, Ltd on behalf of Sichuan International Medical Exchange & Promotion Association (SCIMEA).