Enhancing PD-1 Blockade With CAR-Macrophage Therapy in HER2+ Solid Tumors

Wenxue Ma; Catriona Jamieson

doi:10.1002/mog2.70036

MEDCOMM - Oncology ›› 2025, Vol. 4 ›› Issue (3) : e70036 DOI: 10.1002/mog2.70036

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Enhancing PD-1 Blockade With CAR-Macrophage Therapy in HER2⁺ Solid Tumors

Wenxue Ma ¹
, Catriona Jamieson ¹^,²

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Wenxue Ma, Catriona Jamieson. Enhancing PD-1 Blockade With CAR-Macrophage Therapy in HER2⁺ Solid Tumors. MEDCOMM - Oncology, 2025, 4(3): e70036 DOI:10.1002/mog2.70036

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References

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[1]	S. Pierini, R. Gabbasov, M. C. Oliveira-Nunes, et al., “Chimeric Antigen Receptor Macrophages (CAR-M) Sensitize HER2+ Solid Tumors to PD1 Blockade in Pre-Clinical Models,” Nature Communications 16, no. 1 (2025): 706.

[2]	Q. Chen, L. Lu, and W. Ma, “Efficacy, Safety, and Challenges of CAR T-Cells in the Treatment of Solid Tumors,” Cancers 14, no. 23 (2022): 5983.

[3]	J. Li, P. Chen, and W. Ma, “The Next Frontier in Immunotherapy: Potential and Challenges of CAR-Macrophages,” Experimental Hematology & Oncology 13, no. 1 (2024): 76.

[4]	Y. Liu, H. Tan, and J. Dai, et al., “Targeting Macrophages in Cancer Immunotherapy: Frontiers and Challenges,” Journal of Advanced Research, ahead of print, January 6, 2025: S2090-1232(24)00622-2, https://doi.org/10.1016/j.jare.2024.12.043.

[5]	K. A. Reiss, M. G. Angelos, E. C. Dees, et al., “CAR-Macrophage Therapy for HER2-Overexpressing Advanced Solid Tumors: A Phase 1 Trial,” Nature Medicine 31, no. 4 (2025): 1171-1182.

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2025 The Author(s). MedComm - Oncology published by John Wiley & Sons Australia, Ltd on behalf of Sichuan International Medical Exchange & Promotion Association (SCIMEA).