Lactate: A Key Promoter of Cancer Stem Cells and Implications for Cancer Therapy

Yan Xue; Lin-Zhu Zhang

doi:10.1002/mog2.70034

MEDCOMM - Oncology ›› 2025, Vol. 4 ›› Issue (3) : e70034 DOI: 10.1002/mog2.70034

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Lactate: A Key Promoter of Cancer Stem Cells and Implications for Cancer Therapy

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Yan Xue, Lin-Zhu Zhang. Lactate: A Key Promoter of Cancer Stem Cells and Implications for Cancer Therapy. MEDCOMM - Oncology, 2025, 4(3): e70034 DOI:10.1002/mog2.70034

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References

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[1]	N. T. B. Nguyen, S. Gevers, R. N. U. Kok, et al., “Lactate Controls Cancer Stemness and Plasticity Through Epigenetic Regulation,” Cell Metabolism 37, no. 4 (2025): 903-919.e10.

[2]	J. Chen, Z. Huang, Y. Chen, et al., “Lactate and Lactylation in Cancer,” Signal Transduction and Targeted Therapy 10, no. 1 (2025): 38.

[3]	H. Chen, Y. Li, H. Li, et al., “NBS1 Lactylation Is Required for Efficient DNA Repair and Chemotherapy Resistance,” Nature 631, no. 8021 (2024): 663-669.

[4]	M. J. Rodríguez-Colman, M. Schewe, M. Meerlo, et al., “Interplay Between Metabolic Identities in the Intestinal Crypt Supports Stem Cell Function,” Nature 543, no. 7645 (2017): 424-427.

[5]	Z. Zong, F. Xie, S. Wang, et al., “Alanyl-tRNA Synthetase, AARS1, Is a Lactate Sensor and Lactyltransferase That Lactylates p53 and Contributes to Tumorigenesis,” Cell 187, no. 10 (2024): 2375-2392.e33.

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