Intercellular Mitochondrial Transfer Enhances the Antitumor Immunity of CD8+ T Cells

Ce Guo; Qiqing Yang; Long Zhang

doi:10.1002/mog2.70017

MEDCOMM - Oncology ›› 2025, Vol. 4 ›› Issue (2) : e70017 DOI: 10.1002/mog2.70017

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Intercellular Mitochondrial Transfer Enhances the Antitumor Immunity of CD8⁺ T Cells

Ce Guo ¹^,²
, Qiqing Yang ¹^,²
, Long Zhang ¹^,²^,³

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Ce Guo, Qiqing Yang, Long Zhang. Intercellular Mitochondrial Transfer Enhances the Antitumor Immunity of CD8⁺ T Cells. MEDCOMM - Oncology, 2025, 4(2): e70017 DOI:10.1002/mog2.70017

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References

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[2]	N. E. Scharping, D. B. Rivadeneira, A. V. Menk, et al., “Mitochondrial Stress Induced by Continuous Stimulation Under Hypoxia Rapidly Drives T Cell Exhaustion,” Nature Immunology 22, no. 2 (2021): 205–215.

[3]	T. Saha, C. Dash, R. Jayabalan, et al., “Intercellular Nanotubes Mediate Mitochondrial Trafficking Between Cancer and Immune Cells,” Nature Nanotechnology 17, no. 1 (2022): 98–106.

[4]	S. J. Im, M. Hashimoto, M. Y. Gerner, et al., “Defining CD8+ T Cells That Provide the Proliferative Burst After PD-1 Therapy,” Nature 537, no. 7620 (2016): 417–421.

[5]	M. G. Vander Heiden, L. C. Cantley, and C. B. Thompson, “Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation,” Science 324, no. 5930 (2009): 1029–1033.

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2025 The Author(s). MedComm – Oncology published by John Wiley & Sons Australia, Ltd on behalf of Sichuan International Medical Exchange & Promotion Association (SCIMEA).