RREB1: A Critical Transcription Factor, Integrates TGF-β and RAS Signals to Drive Cancer Metastasis via Regulation of Enhancers

References

[1] J. H.Lee, F. J.Sánchez-Rivera, L.He, et al., “TGF-βand RAS Jointly Unmask Primed Enhancers to Drive Metastasis,” Cell 187, no. 22 (2024):6182–6199.e29.

[2] J.Su, S. M.Morgani, C. J.David, et al., “TGF-βOrchestrates Fibrogenic and Developmental Emts via the RAS Effector RREB1,” Nature 577, no. 7791 (2020):566–571.

[3] A.Thiagalingam, A.Bustros, M.Borges, et al., “Rreb-1, a Novel Zinc Finger Protein, Is Involved in the Differentiation Response to Ras in Human Medullary Thyroid Carcinomas,” Molecular and Cellular Biology 16, no. 10 (1996):5335–5345.

[4] G.Han, M.Cui, P.Lu, et al., “Selective Translation of Nuclear Mitochondrial Respiratory Proteins Reprograms Succinate Metabolism in AML Development and Chemoresistance,” Cell Stem Cell 31, no. 12 (2024):1777–1793.e9.

[5] R.Fontana, A.Mestre-Farrera, and J.Yang, “Update on Epithelial-Mesenchymal Plasticity in Cancer Progression,” Annual Review of Pathology: Mechanisms of Disease 19 (2024):133–156.

RIGHTS & PERMISSIONS

2025 2025 The Author(s). MedComm - Oncology published by John Wiley & Sons Australia, Ltd on behalf of Sichuan International Medical Exchange & Promotion Association (SCIMEA).