RREB1: A Critical Transcription Factor, Integrates TGF-β and RAS Signals to Drive Cancer Metastasis via Regulation of Enhancers

Zhe Wang , Feng Xie , Fangfang Zhou

MEDCOMM - Oncology ›› 2025, Vol. 4 ›› Issue (1) : e70016

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MEDCOMM - Oncology ›› 2025, Vol. 4 ›› Issue (1) : e70016 DOI: 10.1002/mog2.70016
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RREB1: A Critical Transcription Factor, Integrates TGF-β and RAS Signals to Drive Cancer Metastasis via Regulation of Enhancers

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Zhe Wang, Feng Xie, Fangfang Zhou. RREB1: A Critical Transcription Factor, Integrates TGF-β and RAS Signals to Drive Cancer Metastasis via Regulation of Enhancers. MEDCOMM - Oncology, 2025, 4(1): e70016 DOI:10.1002/mog2.70016

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References

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J. H.Lee, F. J.Sánchez-Rivera, L.He, et al., “TGF-βand RAS Jointly Unmask Primed Enhancers to Drive Metastasis,” Cell 187, no. 22 (2024):6182–6199.e29.

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J.Su, S. M.Morgani, C. J.David, et al., “TGF-βOrchestrates Fibrogenic and Developmental Emts via the RAS Effector RREB1,” Nature 577, no. 7791 (2020):566–571.

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A.Thiagalingam, A.Bustros, M.Borges, et al., “Rreb-1, a Novel Zinc Finger Protein, Is Involved in the Differentiation Response to Ras in Human Medullary Thyroid Carcinomas,” Molecular and Cellular Biology 16, no. 10 (1996):5335–5345.

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G.Han, M.Cui, P.Lu, et al., “Selective Translation of Nuclear Mitochondrial Respiratory Proteins Reprograms Succinate Metabolism in AML Development and Chemoresistance,” Cell Stem Cell 31, no. 12 (2024):1777–1793.e9.

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R.Fontana, A.Mestre-Farrera, and J.Yang, “Update on Epithelial-Mesenchymal Plasticity in Cancer Progression,” Annual Review of Pathology: Mechanisms of Disease 19 (2024):133–156.

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2025 The Author(s). MedComm - Oncology published by John Wiley & Sons Australia, Ltd on behalf of Sichuan International Medical Exchange & Promotion Association (SCIMEA).

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