Nanoparticle-encapsuled celastrol-Fe(III): “Single-edged sword” for tumor therapy featuring microenvironmentdependent toxicity

Yu Liu; Zhiyong Qian

doi:10.1002/mog2.70001

MEDCOMM - Oncology ›› 2024, Vol. 3 ›› Issue (4) : e70001 DOI: 10.1002/mog2.70001

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Nanoparticle-encapsuled celastrol-Fe(III): “Single-edged sword” for tumor therapy featuring microenvironmentdependent toxicity

Yu Liu
, Zhiyong Qian ^†

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Yu Liu, Zhiyong Qian. Nanoparticle-encapsuled celastrol-Fe(III): “Single-edged sword” for tumor therapy featuring microenvironmentdependent toxicity. MEDCOMM - Oncology, 2024, 3(4): e70001 DOI:10.1002/mog2.70001

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References

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[1]	LiH, LiY, ZhangL, et al. Prodrug-inspired adenosine triphosphate-activatable celastrol-Fe(Iii) chelate for cancer therapy. Sci Adv. 2024;10(28):eadn0960.

[2]	CorsonTW, CrewsCM. Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell. 2007;130(5):769-774.

[3]	KannaiyanR, HayHS, RajendranP, et al. Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells: celastrol inhibits NF-κB and STAT3 in MM. Br J Pharmacol. 2011;164(5):1506-1521.

[4]	Di VirgilioF, SartiAC, FalzoniS, De Marchi E, AdinolfiE. Extracellular Atp and P2 purinergic signalling in the tumour microenvironment. Nat Rev Cancer. 2018;18(10):601-618.

[5]	GuoJ, PingY, EjimaH, et al. Engineering multifunctional capsules through the assembly of Metal-Phenolic networks. Angew Chem Int Ed. 2014;53(22):5546-5551.

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2024 The Author(s). MedComm – Oncology published by John Wiley & Sons Australia, Ltd on behalf of Sichuan International Medical Exchange & Promotion Association (SCIMEA).