REV-ERBα-Mediated Hepatic Regulation of Cachexia: A Circadian-Metabolic Axis of Tissue Wasting

Wenhui Wang; Junke Song; Gaofei Wei

doi:10.1002/mef2.70038

MEDCOMM - Future Medicine ›› 2025, Vol. 4 ›› Issue (4) : e70038 DOI: 10.1002/mef2.70038

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REV-ERBα-Mediated Hepatic Regulation of Cachexia: A Circadian-Metabolic Axis of Tissue Wasting

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Wenhui Wang, Junke Song, Gaofei Wei. REV-ERBα-Mediated Hepatic Regulation of Cachexia: A Circadian-Metabolic Axis of Tissue Wasting. MEDCOMM - Future Medicine, 2025, 4(4): e70038 DOI:10.1002/mef2.70038

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References

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[1]	D. Kaltenecker, S. Fisker Schmidt, P. Weber, et al., “Functional Liver Genomics Identifies Hepatokines Promoting Wasting in Cancer Cachexia,” Cell 188, no. 17 (2025): 4549-4566.e22.

[2]	T. Setiawan, I. N. Sari, Y. T. Wijaya, et al., “Cancer Cachexia: Molecular Mechanisms and Treatment Strategies,” Journal of Hematology & Oncology 16, no. 1 (2023): 54.

[3]	D. Wang, X. Li, D. Jiao, et al., “LCN2 Secreted by Tissue-Infiltrating Neutrophils Induces the Ferroptosis and Wasting of Adipose and Muscle Tissues in Lung Cancer Cachexia,” Journal of Hematology & Oncology 16, no. 1 (2023): 30.

[4]	A. Garrett, N. Darzi, A. Deshmukh, et al., “Vagal Blockade of the Brain-Liver Axis Deters Cancer-Associated Cachexia,” Cell 188 (2025): 6044-6063.e24.

[5]	G. Ding, X. Li, X. Hou, et al., “REV-ERB in GABAergic Neurons Controls Diurnal Hepatic Insulin Sensitivity,” Nature 592, no. 7856 (2021): 763-767.

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2025 The Author(s). MedComm - Future Medicine published by John Wiley & Sons Australia, Ltd on behalf of Sichuan International Medical Exchange & Promotion Association (SCIMEA).