The Sentinel's Betrayal: A STING-Driven Necroptotic Axis in Caspase-8-Deficient Pathology and STING-Associated Vasculopathy With Onset in Infancy (SAVI)

Xin He; Bin Wang; Long Zhang

doi:10.1002/mef2.70037

MEDCOMM - Future Medicine ›› 2025, Vol. 4 ›› Issue (4) : e70037 DOI: 10.1002/mef2.70037

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The Sentinel's Betrayal: A STING-Driven Necroptotic Axis in Caspase-8-Deficient Pathology and STING-Associated Vasculopathy With Onset in Infancy (SAVI)

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Xin He, Bin Wang, Long Zhang. The Sentinel's Betrayal: A STING-Driven Necroptotic Axis in Caspase-8-Deficient Pathology and STING-Associated Vasculopathy With Onset in Infancy (SAVI). MEDCOMM - Future Medicine, 2025, 4(4): e70037 DOI:10.1002/mef2.70037

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References

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[1]	K. Kelepouras, J. Saggau, D. Bonasera, et al., “STING Induces ZBP1-Mediated Necroptosis Independently of TNFR1 and FADD,” Nature, ahead of print, August 20, 2025. https://doi.org/10.1038/s41586-025-09536-4.

[2]	G. Liccardi and A. Annibaldi, “MLKL Post-Translational Modifications: Road Signs to Infection, Inflammation and Unknown Destinations,” Cell Death and Differentiation 30, no. 2 (2023): 269-278.

[3]	A. Kovalenko, J. C. Kim, T. B. Kang, et al., “Caspase-8 Deficiency in Epidermal Keratinocytes Triggers an Inflammatory Skin Disease,” Journal of Experimental Medicine 206, no. 10 (2009): 2161-2177.

[4]	K. Kelepouras, J. Saggau, A. B. Varanda, et al., “The Importance of Murine Phospho-MLKL-S345 In Situ Detection for Necroptosis Assessment In Vivo,” Cell Death and Differentiation 31, no. 7 (2024): 897-909.

[5]	G. Liccardi, L. Ramos Garcia, T. Tenev, et al., “RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation,” Molecular Cell 73, no. 3 (2019): 413-428.e7.

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