Transsulfuration Reprogramming: A Metabolic Driver of BRAF-V600E Resistance in Melanoma

Juntong Chen; Guoqing Ding; Jie Zhang

doi:10.1002/mef2.70024

MEDCOMM - Future Medicine ›› 2025, Vol. 4 ›› Issue (2) : e70024 DOI: 10.1002/mef2.70024

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Transsulfuration Reprogramming: A Metabolic Driver of BRAF-V600E Resistance in Melanoma

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Juntong Chen, Guoqing Ding, Jie Zhang. Transsulfuration Reprogramming: A Metabolic Driver of BRAF-V600E Resistance in Melanoma. MEDCOMM - Future Medicine, 2025, 4(2): e70024 DOI:10.1002/mef2.70024

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References

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[1]	K. Borbényi-Galambos, K. Erdélyi, T. Ditrói, et al., “Realigned Transsulfuration Drives BRAF-V600E-Targeted Therapy Resistance in Melanoma,” Cell Metabolism 37, no. 5 (2025): 1171–1188.

[2]	A. Hall, K. D. Meyle, M. K. Lange, et al., “Dysfunctional Oxidative Phosphorylation Makes Malignant Melanoma Cells Addicted to Glycolysis Driven by the (V600E)BRAF Oncogene,” Oncotarget 4, no. 4 (2013): 584–599.

[3]	J. A. Sosman, K. B. Kim, L. Schuchter, et al., “Survival in BRAF V600-Mutant Advanced Melanoma Treated With Vemurafenib,” New England Journal of Medicine 366, no. 8 (2012): 707–714.

[4]	T. Featherston, M. Paumann-Page, and M. B. Hampton, “Melanoma Redox Biology and the Emergence of Drug Resistance,” Advances in Cancer Research 162 (2024): 145–171.

[5]	T. Ida, T. Sawa, H. Ihara, et al., “Reactive Cysteine Persulfides and S-Polythiolation Regulate Oxidative Stress and Redox Signaling,” Proceedings of the National Academy of Sciences 111, no. 21 (2014): 7606–7611.

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