Lithocholic Acid Activates TULP3-Sirtuin-v-ATPase-AMPK Axis to Enhance Longevity

Yiran Wu; Zhengyu Gao; Long Zhang

doi:10.1002/mef2.70017

MEDCOMM - Future Medicine ›› 2025, Vol. 4 ›› Issue (1) : e70017 DOI: 10.1002/mef2.70017

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Lithocholic Acid Activates TULP3-Sirtuin-v-ATPase-AMPK Axis to Enhance Longevity

Yiran Wu ¹
, Zhengyu Gao ¹
, Long Zhang ¹^,²^,³^,^†

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Yiran Wu, Zhengyu Gao, Long Zhang. Lithocholic Acid Activates TULP3-Sirtuin-v-ATPase-AMPK Axis to Enhance Longevity. MEDCOMM - Future Medicine, 2025, 4(1): e70017 DOI:10.1002/mef2.70017

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References

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[1]	Q.Qu, Y.Chen, Y.Wang, et al., “Lithocholic Acid Phenocopies Anti-Ageing Effects of Calorie Restriction,” Nature, ahead of print, December 18, 2024, https://doi.org/10.1038/s41586-024-08329-5.

[2]	Qu, Y.Chen, Y.Wang, et al., “Lithocholic Acid Binds TULP3 to Activate Sirtuins and AMPK to Slow Down Ageing,” Nature, ahead of print, December 18, 2024, https://doi.org/10.1038/s41586-024-08348-2.

[3]	L.Fontana, L.Partridge, and V. D.Longo, “Extending Healthy Life Span—From Yeast to Humans,” Science 328, no. 5976 (2010):321–326.

[4]	A. J.Dirks and C.Leeuwenburgh, “Caloric Restriction in Humans: Potential Pitfalls and Health Concerns,” Mechanisms of Ageing and Development 127, no. 1 (2006):1–7.

[5]	C. S.Zhang, S. A.Hawley, Y.Zong, et al., “Fructose-1,6-Bisphosphate and Aldolase Mediate Glucose Sensing by AMPK,” Nature 548, no. 7665 (2017):112–116.

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2025 The Author(s). MedComm - Future Medicine published by John Wiley & Sons Australia, Ltd on behalf of Sichuan International Medical Exchange & Promotion Association (SCIMEA).