Human iPSC-derived self-assembled cardiac organoids for evaluating drug developmental cardiotoxicity

References

[1] Yi F , Liu G-H , Izpisua Belmonte JC , et al. Human induced pluripotent stem cells derived hepatocytes:rising promise for disease modeling, drug development and cell therapy. Protein & Cell 2012; 3: 246- 250.

[2] Chen Q , Gan Y , Wang K , et al. PregTox:a resource of knowledge about drug fetal toxicity. Biomed Res Int 2022; 2022: 4284146.

[3] Niehrs C . Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 2006; 25: 7469- 81.

[4] Caprioli A , Koyano-Nakagawa N , Iacovino M , et al. Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis. Circulation 2011; 123: 1633- 41.

[5] Ni M , Li Y , Wei J , et al. Increased Ca(2+) transient underlies RyR2-related left ventricular noncompaction. Circ Res 2023; 133: 177- 92.

[6] Yellen G . The voltage-gated potassium channels and their relatives. Nature 2002; 419: 35- 42.

[7] Liang X , Evans SM , Sun Y . Insights into cardiac conduction system formation provided by HCN4 expression. Trends Cardiovasc Med 2015; 25: 1- 9.

[8] Veerman CC , Wilde AA , Lodder EM . The cardiac sodium channel gene SCN5A and its gene product NaV1.5:role in physiology and pathophysiology. Gene 2015; 573: 177- 87.

[9] Sun Y , Liang X , Najafi N , et al. Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol 2007; 304: 286- 96.

[10] Cai N , Li M , Qu J et al. Post-translational modulation of pluripotency. Journal of Molecular Cell Biology. 2012; 4: 262- 5.

RIGHTS & PERMISSIONS

The Author(s). Published by Oxford University Press on behalf of Higher Education Press.