Acute ischemic stroke is often accompanied by complications such as infection. After acute ischemic stroke, immunosuppression can occur as a mechanism to prevent an excessive inflammatory response. Glucocorticoid, an important product of the hypothalamic-pituitary-adrenal axis, plays a crucial role in inducing immunosuppression in the early stage of acute cerebral infarction. Glucocorticoid not only affects the secretion of inflammatory cytokines but also influences the function of immune cells, ultimately leading to an increased risk of infection.

The health status of the floating elderly population and the need of community management services are complex and important problems. Owing to the change of living environment and the insecure medical care, the mobile elderly people have more health and psychological problems compared to the rest of the elderly population. Therefore, the community should take a variety of measures to meet their needs and help them to better adapt to the new living environment, and maintain their physical and mental health. This paper aims to summarize recent studies on the physical and emotional health problems of mobile elderly people and related community management service needs.

Acarbose is used to control postprandial blood glucose in patients with type 2 diabetes and impaired glucose tolerance, since it improves insulin resistance and reduces blood lipids and cardiovascular complications. However, in recent years, many studies have found that acarbose can mediate and regulate a variety of neurotransmitter-related diseases, although the mechanisms are not clear. Therefore, this paper analyzes the clinical effect of acarbose and its mediating effect on neurotransmitters of mental disorders through insulin, brain-gut axis, and calorie restriction, to provide a reference for the new clinical applications of acarbose.

Objective: To observe the effects of remote ischemia on cognitive function and neuronal pathological damage in rats with cognitive impairment induced by bilateral common carotid artery occlusion (BCAO). Methods: Male SD rats were selected to establish the cognitive impairment model induced by cerebral ischemia reperfusion caused by BCAO. The tests included three groups of rats: a sham group, a model group with vascular cognitive impairment (VCI) , and a remote ischemic conditioning (RIC) group (VCI + RIC group). From 24 h after operation, both hind limbs of rats in VCI+RIC group were treated with RIC. After 28 d, Morris water maze test and HE staining was used to observe the pathological changes of white matter and hippocampus in each group. Results: After 3 d mice in VCI group began to improve gradually. The recovery of rats in the VCI + RIC group was relatively slow, but they started to recover rapidly 2 d after the operation. Morris water maze test showed that the escape latency of rats in VCI group and VCI+RIC group was longer than that in the sham group, and the score of VCI+RIC group was better than that of the VCI group, but there was a significant difference between the two groups (P＜0.05). The space exploration experiment was performed at 7 d and 28 d after the operation; the VCI+RIC group outperformed the VCI group in both trials; the difference between the two groups was statistically significant (P＜0.05). In the target quadrant exploration time, the difference between the VCI group (33.5±11.3 s) and the VCI+RIC group (41.2±9.7 s) was statistically significant (P＜0.05). Results from the hematoxylin and eosin (HE) staining showed that compared with VCI group, cortical cells in VCI + RIC group had loose stroma, thinner nerve fibers, fewer broken cells, and slightly shrunken cells. Compared with VCI group, neurons in VCI + RIC group had a little vacuolar degeneration and slightly shrunken cell volume. Conclusion: Cerebral ischemia-reperfusion injury can cause learning and memory impairment in rats, leading to VCI. RIC can significantly improve VCI and play a neuroprotective role.

Objective: To describe the clinical features of autoimmune encephalitis complicated with gastrointestinal hemorrhage. Methods: The clinical data of one patient whose initial symptom was mental abnormality were collected and the related examinations, such as cerebrospinal fluid and magnetic resonance imaging (MRI), were improved. Results: Cerebrospinal fluid examination found that anti-α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) 2 antibody was strongly positive, although the patient had repeated gastrointestinal hemorrhage but, after hormone combined with immunoglobulin treatment, the symptoms gradually improved. Conclusion: Mental disorders are not all psychosis, and autoimmune encephalitis should not be ignored. It is very important to perform anti-AMPAR encephalitis antibody test; accurate diagnosis and timely treatment can improve the prognosis.