Advances in glucocorticoid-mediated stroke-associated immunosuppression

Abstract

Acute ischemic stroke is often accompanied by complications such as infection. After acute ischemic stroke, immunosuppression can occur as a mechanism to prevent an excessive inflammatory response. Glucocorticoid, an important product of the hypothalamic-pituitary-adrenal axis, plays a crucial role in inducing immunosuppression in the early stage of acute cerebral infarction. Glucocorticoid not only affects the secretion of inflammatory cytokines but also influences the function of immune cells, ultimately leading to an increased risk of infection.

Keywords

acute ischemic stroke / stroke-associated immunosuppression / hypothalamic-pituitary-adrenal axis / glucocorticoid