Clinical features of AMPAR2 antibody-positive autoim- mune encephalitis with gastrointestinal hemorrhage: a case report

Abstract

Objective: To describe the clinical features of autoimmune encephalitis complicated with gastrointestinal hemorrhage. Methods: The clinical data of one patient whose initial symptom was mental abnormality were collected and the related examinations, such as cerebrospinal fluid and magnetic resonance imaging (MRI), were improved. Results: Cerebrospinal fluid examination found that anti-α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) 2 antibody was strongly positive, although the patient had repeated gastrointestinal hemorrhage but, after hormone combined with immunoglobulin treatment, the symptoms gradually improved. Conclusion: Mental disorders are not all psychosis, and autoimmune encephalitis should not be ignored. It is very important to perform anti-AMPAR encephalitis antibody test; accurate diagnosis and timely treatment can improve the prognosis.

Keywords

gastrointestinal hemorrhage / autoimmune encephalitis / α-Amino-3-hydroxy-5-methylisox-azole-4-propionic acid subtype glutamate receptor (AMPAR) / cerebrospinal fluid