Brain-derived neurotrophic factor (BDNF) plays an important role in the growth, development, differentiation, injury, repair, survival and apoptosis of nerve cells. Precursor of BDNF (proBDNF) is an important regulator of neurodegeneration, long-term hippocampal inhibition and synaptic plasticity. Alcohol dependence syndrome (ADS) is a group of chronic recurrent diseases with unknown etiology. Current studies believe that proBDNF plays an important role in the occurrence, development and outcome of ADS. Alcohol dependence patients, like other neurodegenerative diseases, will also have different degrees of cognitive impairment. This article reviews the research progress on the relationship between BDNF, proBDNF, alcohol dependence and cognitive impairment.

In recent years, non-suicidal self-injury (NSSI) behavior has emerged in a large number of adolescent depression. NSSI associated with adolescent depression may be an addictive behavior, which has many similar neurobiological mechanisms to substance addiction. Brain-derived neurotrophic factor (BDNF) and precursor of BDNF (proBDNF) play an important role in addiction behavior, and they may be related to endogenous opioid receptors. The location and distribution of opioid μ receptors in the brain are related to reward, motivation and emotion regulated by behavioral addiction. The purpose of this paper is to review the general situation, mechanism and relationship between the characteristics of NSSI behavior addiction and brain-derived nutritional factors in adolescents with depression.

Brain-derived neurotrophic factor (BDNF) is a widely studied neurotrophic factor, which plays an important role in the growth, development, differentiation, injury, repair, survival and apoptosis of nerve cells. More and more studies have found that there is a high prevalence of depressive disorders in patients with autoimmune diseases. Sjögren’s syndrome is a chronic autoimmune exocrine disease characterized by lymphocytic infiltration and exocrine gland destruction. Depressive disorders are common in patients with Sjögren’s syndrome. The quality of life of patients with Sjögren’s syndrome with depression was generally lower than that of patients with Sjögren’s syndrome without depression. In this article, we reviewed the research progress of BDNF and depression in Sjögren’s syndrome at home and abroad.

In recent years, the serious social phenomenon of suicide has been of great concern to society and academia. However, the study and early risk assessment of suicide have been limited by multiple aspects. Therefore, researchers have started to search for a reliable marker for early diagnosis of suicide risk, and one of the widely studied neurotransmitters associated with suicide is the brain-derived neurotrophic factor (BDNF). This review aims to summarize the current scientific knowledge on the relevance of BDNF and psychiatric disorders to suicide and to infer whether neurotrophic factors could be a reliable marker for early diagnosis of suicide risk. Based on the results of these studies, a link between BDNF and suicide may exist and act independently of mental illness. However, there is still controversy and further studies may provide researchers with useful information.