Research progress on the relationship between proBDNF and alcohol dependence and its related cognitive impairment

Abstract

Brain-derived neurotrophic factor (BDNF) plays an important role in the growth, development, differentiation, injury, repair, survival and apoptosis of nerve cells. Precursor of BDNF (proBDNF) is an important regulator of neurodegeneration, long-term hippocampal inhibition and synaptic plasticity. Alcohol dependence syndrome (ADS) is a group of chronic recurrent diseases with unknown etiology. Current studies believe that proBDNF plays an important role in the occurrence, development and outcome of ADS. Alcohol dependence patients, like other neurodegenerative diseases, will also have different degrees of cognitive impairment. This article reviews the research progress on the relationship between BDNF, proBDNF, alcohol dependence and cognitive impairment.

Keywords

alcohol dependence syndrome (ADS) / brain-derived neurotrophic factor (BDNF) / precursor of BDNF (proBDNF) / cognition