Research progress on brain-derived neurotrophic factor and non-suicidal self-injury addictive behavior associated with depressive disorders in adolescents

Abstract

In recent years, non-suicidal self-injury (NSSI) behavior has emerged in a large number of adolescent depression. NSSI associated with adolescent depression may be an addictive behavior, which has many similar neurobiological mechanisms to substance addiction. Brain-derived neurotrophic factor (BDNF) and precursor of BDNF (proBDNF) play an important role in addiction behavior, and they may be related to endogenous opioid receptors. The location and distribution of opioid μ receptors in the brain are related to reward, motivation and emotion regulated by behavioral addiction. The purpose of this paper is to review the general situation, mechanism and relationship between the characteristics of NSSI behavior addiction and brain-derived nutritional factors in adolescents with depression.

Keywords

brain-derived neurotrophic factor (BDNF) / precursor of BDNF (proBDNF) / adolescents / depressive disorder / non-suicidal self-injury (NSSI) / addictive behavior