Progress in the correlation between chronic insomnia disorder and cytokines

Abstract

Chronic insomnia disorder (CID) is a relatively common clinical sleep disorder, which is essentially characterized by dissatisfaction with sleep due to frequent and persistent difficulties in falling asleep or maintaining sleep. The etiology and pathogenesis of CID are not fully understood. In the past decades, medical research has explored the interrelationship between cytokines (CKs) and sleep disorders, and this paper reviews the correlation between CID and inflammatory factors in the context of domestic and international research on the subject.

Keywords

chronic insomnia disorder (CID) / cytokine (CK) / interleukin (IL)-6 / IL-8 / IL-1β / tumor necrosis factor-α(TNF-α)