Inclusion of human centromeres in genomic browsers – will it finally come?

References

[1] Jaggi KE,O'Neill RJ.A genomic and epigenomic view of human centromeres.Nat Rev Genet.2026;Online ahead of print

[2] Nurk S,Rhie A.The complete sequence of a human genome.Science.2022;376:44-53

[3] Liehr T.Repetitive elements in humans.Int J Mol Sci.2021;22:2072 PMCID:PMC7922087

[4] Logsdon GA,Audano PA.Complex genetic variation in nearly complete human genomes.Nature.2025;644:430-41 PMCID:PMC12350169

[5] Corda L,Dallali H.Cell line-matched reference enables high-precision functional genomics.Nat Commun.2025;16:11194 PMCID:PMC12711918

[6] Liehr T.Benign & pathological chromosomal imbalances. In: Microscopic and submicroscopic copy number variations (CNVs) in genetics and counseling, 1st ed. Oxford: Academic Press; 2014.

[7] Liehr T.About classical molecular genetics, cytogenetic and molecular cytogenetic data not considered by Genome Reference Consortium and thus not included in genome browsers like UCSC, Ensembl or NCBI.Mol Cytogenet.2021;14:20

[8] ISCN 2024 - an international system for human cytogenomic nomenclature (2024).Cytogenet Genome Res.2024;164:1-224

[9] Liehr T. ChromoSomics databases. Available from: https://cs-tl.de/Start.html [Last accessed on 22 Apr 2026]

[10] Baldini A,Shridhar V,Miller OJ.Comparative mapping of a gorilla-derived alpha satellite DNA clone on great ape and human chromosomes.Chromosoma.1991;101:109-14

[11] Weise A,Alves G.Satellite DNA amplification in advanced prostate cancer is largely independent from euchromatic and oncogene amplicons.J Histochem Cytochem.2025;73:109-13 PMCID:PMC11915227

[12] Liehr T.Chromosomal Heteromorphisms and Cancer Susceptibility Revisited.Cells.2022;11:3239 PMCID:PMC9600968