A mini review of noncoding RNAs in the pathogenesis of polycystic kidney disease

Abstract

Polycystic kidney disease (PKD) is a genetic disorder characterized by the growth of numerous cysts in the kidneys, leading to kidney enlargement and progressive renal failure. Recent advances have indicated a pivotal role of noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular RNAs (circRNAs) and PIWI-interacting RNAs (piRNAs), in the pathogenesis of PKD, potentially through regulating gene expression and cellular processes related to cyst formation, inflammation, and fibrosis. This review summarizes current knowledge of noncoding RNAs, explores their potential as biomarkers and therapeutic targets, and proposes potential directions for future research to further elucidate their roles in disease progression.

Keywords

Noncoding RNA / polycystic kidney disease / therapeutic target / miRNA / lncRNA / gene expression / signaling pathway

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