Chemical Property and Antibacterial Activity of Metronidazole-decorated Ti through Adhesive Dopamine

Abstract

In order to present a novel metronidazole-decorated Ti implanted with antibacterial activity through adhesive dopamine, and prepare metronidazole-decorated Ti, Ti substrates were pre-modified with dopamine (DA) coating, and metronidazole was subsequently immobilized onto the surface of DA-modified Ti substrates. The prepared MET-decorated Ti interfaces were prepared for surface characterization tests: contacting angle measurements, scanning electron microscope, ATR-FTIR spectroscopy and in vitro anti-biofilm formation assay. Statistical tests were performed using by SPSS16.0. Contacting angle measurement, scanning electron microscopy, and ATR-FTIR spectroscopy confIrmed the successful presence of MET grafted on the Ti surface. In addition, the MET-decorated Ti induced good in vitro antibacterial activity toward Escherichia coli and Streptococcus mutans,Gram-negative and Gram-positive bacteria, respectively. The modified Ti substrate with enhanced antibacterial activity holds a great potential as implanting material for applications in dental and bone graft substitutes.

Keywords

dopamine / metronidazole-decorated / antibacterial activity

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