Mechanism of fixation of ozone and its medical value

Abstract

Because of both ozone gas and ozone solution are instable which limits the application of ozone, to solve the storage problem, it is necessary to find a kind of ideal ozone carrier which can combine ozone as an “ozonic compound” in which the bond strength between ozone and carrier should not be too high or too low, to appropriately release ozone from the ozonic compound. Combining Criegee’s three-step reaction mechanism of ozone and olefins, the charge, covalent bond levels and energy levels of ozone, ethylene, butadiene and their ozonic compounds were calculated by the first-principles calculation method based on density functional theory methods. The stability of the ozonide, or the bond strength between ozone and ions of carrier were controlled felicitously to release ozone from the ozonide with proper velocity. Ozone antimicrobial was composed on the above principle. It can be used conveniently, especially for common families.

Keywords

ozone / fixation carrier / release velocity / antimicrobial

References

[1] Travagli V, Zanardi I, Valacchi G, . Ozone and Ozonated Oils in Skin Diseases: A Review[J]. Mediators of Inflammation, 2010 1-10.

[2] Travagli V, Zanardi I, Silvietti A, . A Physicochemical Investigation on the Effects of Ozone on Blood[J]. Int. J. Biological Macromolecules, 2007, 41(5): 504-511.

[3] Bocci V Ozone-A New Medical Drug[M], 2005 Netherlandsm Kluwer Academic Pub-lishers 1-295.

[4] Valacchi G, Bocci V Studies on the Biological Effects of Ozone: 11 Release of Factors from Human Endothelial Cells[J]. Mediators of Inflammation, 2000, 9(6): 271-276.

[5] Muminov A I, Khushvakova N Ozone Therapy in Patients with Chronic Purulent Frontal Sinusitis[J]. Vestn-Otorinolaringol, 2002, 6: 46-48.

[6] Li H J, Geng K S, Wu C P, . Curative Effect of Ozone Liquid Vaginitis in Treatment[J]. International Medicine & Health Guidance News, 2007, 13(3): 4-7.

[7] Tylicki L, Biedunkiewicz B, Nieweglowski T, . Ozonated Autohemotherapy in Patients on Maintenance Hemodialysis: Influence on Lipid profile and Endothelium[J]. Artif Organs, 2004, 28(2): 234-237.

[8] Andreula CF, Simonetti L, De Santis F, . Minimally Invasive Oxygen-ozone Therapy for Lumbar Disk Herniation[J]. AJNR. Am. J. Neuroradiol., 2003, 24(5): 996-1 000.

[9] Bocci V A reasonable Approach for the Treatment of HIV Infection in the Early Phase with Ozonetherapy (Autohaemotherapy): How ‘Inflammatory’ Cytokines may have A therapeutic Role[J]. Mediators of Inflammation, 1994, 3(5): 315-321.

[10] Ellis DE, Guenzburger D The Discrete Variational Method in Density Functional Theory and Its Applications to Large Molecules and Solidstate Systems[J]. Advances in Quantum Chemistry, 1999, 34: 51-141.

[11] Criegee R Mechanism of Ozonolysis[J]. Angewandte Chemistry, 1975, 87: 765-771.