The nano pulverization of traditional Chinese medicine Liuwei Dihuang

Abstract

The crude drug of Liuwei Dihuang was pulverized to nano particles to improve its bioavailability. The appropriate technique parameters were studied. Paeonol, typical marker of Liuwei Dihuang, was extracted with organic solvent in ultrasonic and its content was determined by HPLC. The appropriate techniques parameters are as follows: rotating speed control 1200 r/min, grinding time control 50 min and mass percent concentration control 3.8%. The experimental results show that the average particle diameter is 161.9 nm and the great majority of the plant cell wall is broken into pieces after nano pulverization. The extraction efficiency of paeonol is increased by 23.5%.

Keywords

HSCS pulverizer / Liuwei Dihuang / nano particles / paeonol

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