Self-encoding functional resin applying for combinatorial chemistry and high throughput screening

Abstract

A novel solid phase organic synthesis resin was synthesized for combinatorial high-throughput screening, which based on FTIR spectra self-encoding functional resin technology. A new deconvolution strategy termed position encoding deconvolution had illustrated and was compared with some popular combinatorial deconvolution strategies in efficiency and information content. The mimic high throughput screening of hexapeptide library successfully, proved the applying of the self-encoding functional resin technology and the position encoding deconvolution strategy.

Keywords

combinatorial / encoding / FTIR / high throughput screening / resin

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