Exercise Training for the Elderly: Inflammaging and the Central Role for HSP70

Carlos Henrique de Lemos Muller; Jorge Roberto de Matos; Gisele Bettú Grigolo; Helena Trevisan Schroeder; Josianne Rodrigues-Krause; Mauricio Krause

doi:10.1007/s42978-019-0015-6

Journal of Science in Sport and Exercise ›› 2019, Vol. 1 ›› Issue (2) : 97-115. DOI: 10.1007/s42978-019-0015-6

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Exercise Training for the Elderly: Inflammaging and the Central Role for HSP70

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Abstract

Inflammation is a common feature of aging tissues, being involved in most, if not all, age-related diseases. The origin of a low-grade inflammation state in aging (inflammaging) is multifactorial and may involve changes in body composition, immunosenescence, autophagy, microbiota modification and loss of proteostasis. The heat shock response pathway (HSR, and HSP70 expression) plays an important role as a mechanism of resolution of inflammation and proteostasis control. In this review, we sought to discuss the mechanisms that may lead to inflammaging, and the importance of the HSP70 in this process. Besides, we also discuss how physical exercise, particularly resistance training, can improve the HSR and the inflammatory balance of elderly people.

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Carlos Henrique de Lemos Muller, Jorge Roberto de Matos, Gisele Bettú Grigolo, Helena Trevisan Schroeder, Josianne Rodrigues-Krause, Mauricio Krause. Exercise Training for the Elderly: Inflammaging and the Central Role for HSP70. Journal of Science in Sport and Exercise, 2019, 1(2): 97‒115 https://doi.org/10.1007/s42978-019-0015-6