Synthesis and characterization of Fe₃O₄ magnetic nanoparticles and their heating effects under radiofrequency capacitive field

Abstract

Fe₃O₄ magnetic nanoparticles with diameters varying from 10 to 426 nm were synthesized and characterized. Heating effects of Fe₃O₄ magnetic nanoparticles under radiofrequency capacitive field (RCF) with frequency of 27.12 MHz and power of 60–150 W were investigated. When the power of RCF is lower than 90 W, temperatures of Fe₃O₄ magnetic nanoparticles (75–150 mg/mL) can be raised and maximal temperatures are all lower than 50 °C. When the power of RCF is 90–150 W, temperatures of Fe₃O₄ magnetic nanoparticles can be quickly raised and are all obviously higher than those of normal saline and distilled water under the same conditions. Temperature of Fe₃O₄ magnetic nanoparticles can even reach 70.2 °C under 150 W RCF. Heating effects of Fe₃O₄ magnetic nanoparticles are related to RCF power, particle size and particle concentration.

Keywords

Fe₃O₄ / magnetic nanoparticles / radiofrequency capacitive field / synthesis / characterization; heating effects

References

[1] LaurenceD. E., HerveeM., KatelH., EmilieM., MartinS., ClaudeL., PierreD., IgorC.. Nanovectors for anticancer agents based on superparamagnetic iron oxide nanoparticles [J]. Int J Nanomedicine, 2007, 2(4): 541-550

[2] JohannsenM., JordanA., ScholzR., KochM., LeinM., DegerS., RoigasJ., JungK., LoeningS.. Evaluation of magnetic fluid hyperthermia in a standard rat model of prostate cancer [J]. J Endourol, 2004, 18(5): 495-500

[3] LatorreM., RinaldiC.. Applications of magnetic nanoparticles in medicine: Magnetic fluid hyperthermia [J]. P R Health Sci J, 2009, 28(3): 227-238

[4] ShidoY., NishidaY., SuzukiY., KobayashiT., IshiguroN.. Targeted hyperthermia using magnetite cationic liposomes and an alternating magnetic field in a mouse osteosarcoma model [J]. J Bone Joint Surg Br, 2010, 92(4): 580-585

[5] GuoZ.-h., TangL.-X., TangJ.-t., XieB., DengX.-hui.. Development of measurement and control technologies for hyperthermia treatments of tumors with AC magnetic field [J]. Chinese Journal of Medical Instrumentation, 2006, 30(1): 39-42

[6] LiuX., XuB., XiaQ.-s., ZhaoT.-d., TangJ.-tian.. A method of showing thermal effect of iron oxide nanoparticles in alternating magnetic field [J]. Chinese Journal of Cancer, 2005, 24(9): 1148-1150

[7] HergtR., DutzS.. Magnetic particle hyperthermia: Biophysical limitations of a visionary tumour therapy [J]. J Magn Magn Mater, 2005, 293: 80-86

[8] MaM., WuY., ZhouJ., SunY.-k., ZhangY., GuNing.. Size dependence of specific power absorption of Fe₃O₄ particles in AC magnetic field [J]. J Magn Magn Mater, 2004, 268: 33-39

[9] HabashR. W., BansalR., KrewskiD., AlhafidH. T.. Thermal therapy. Part I: An introduction to thermal therapy [J]. Crit Rev Biomed Eng, 2006, 34: 459-489

[10] PalussiereJ., DescatE., FonckM., BonichonF., ChomyF., BecouarnY., AvrilA., KindM., RavaudA.. Radiofrequency ablation in the treatment of liver and lung tumors [J]. Bull Cancer, 2009, 96(11): 1099-1109

[11] HabashR. W., BansalR., KrewskiD., AlhafidH. T.. Thermal therapy. Part II: Hyperthermia techniques [J]. Crit Rev Biomed Eng, 2006, 34(6): 491-542

[12] StaufferP. R.. Evolving technology for thermal therapy of cancer [J]. Int J Hyperthermia, 2005, 21(8): 731-744

[13] MOLDAY R S. Magnetic iron-dextran microspheres: US, 4452773 [P]. 1984-06-05.

[14] SugimotoT., MatijevicE.. Formation of uniform spherical magnetite particles by crystallization from ferrous hydroxide gels [J]. J Colloid Interface Sci, 1980, 74: 227-243

[15] DuY.-q., ZhangD.-s., NiH.-y., GuN., YanS.-y., TangQ.-s., JinL.-q., WanM.-ling.. Preparation and characterization of Fe₃O₄ nano-magnetic particles for tumor hyperthermia [J]. Journal of Chinese Electron Microscopy Society, 2005, 24(6): 608-612

[16] OhguriT., ImadaH., YahataK., MoriokaT., NakanoK., TerashimaH., KorogiY.. Radiotherapy with 8-MHz radiofrequency-capacitive regional hyperthermia for stage III non-small-cell lung cancer: The radiofrequency-output power correlates with the intraesophageal temperature and clinical outcomes [J]. Int J Radiat Oncol Biol Phys, 2009, 73(1): 128-135

[17] ShieldsN., O’HareN., GormleyJ.. An evaluation of safety guidelines to restrict exposure to stray radiofrequency radiation from short-wave diathermy units [J]. Phys Med Biol, 2004, 49(13): 2999-3015

[18] WanB.-k., ZhuX., ChengX.-m., ZhangL.-x., LinS.-y., WangWei.. Parameter optimization of temperature field in RF-capacitive hyperthermia [J]. Progress in Natural Science, 2001, 11(9): 667-674

[19] HabashR. W., BansalR., KrewskiD., AlhafidH. T.. Thermal therapy. Part IV: Electromagnetic and thermal dosimetry [J]. Crit Rev Biomed Eng, 2007, 35: 123-182

[20] JordanA., ScholzR., Maier-hauK., JohannsenM., WustP., NadobnyJ., SchirraH., SchmidtH., DegerS., LoeningS., LankschW., FelixR.. Presentation of a new magnetic field therapy system for the treatment of human solid tumors with magnetic fluid hyperthermia [J]. J Magn Magn Mater, 2001, 225: 118-126

[21] HeH.-w., LiuH.-j., ZhouK.-c., WangW., RongP.-fei.. Characteristics of magnetic Fe₃O₄ nanoparticles encapsulated with human serum albumin [J]. J Cent South Univ Technol, 2006, 13(3): 6-11

[22] MatsuiY., NakagawaA., KamiyamaY., YamamotoK., KuboN., NakaseY.. Selective thermocoagulation of unresectable pancreatic cancers by using radiofrequency capacitive heating [J]. Pancreas, 2000, 20(1): 14-20