Cardiac Autonomic Dysfunction in Obstructive Sleep Apnea: The Hidden Role of Vitamin D Deficiency

Huai Heng Loh , Siow Phing Tay , Ai Jiun Koa , Mei Ching Yong , Asri Said , Chee Shee Chai , Natasya Marliana Abdul Malik , Anselm Ting Su , Bonnie Bao Chee Tang , Florence Hui Sieng Tan , Norlela Sukor

Journal of Evidence-Based Medicine ›› 2025, Vol. 18 ›› Issue (3) : e70071

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Journal of Evidence-Based Medicine ›› 2025, Vol. 18 ›› Issue (3) : e70071 DOI: 10.1111/jebm.70071
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Cardiac Autonomic Dysfunction in Obstructive Sleep Apnea: The Hidden Role of Vitamin D Deficiency

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Huai Heng Loh, Siow Phing Tay, Ai Jiun Koa, Mei Ching Yong, Asri Said, Chee Shee Chai, Natasya Marliana Abdul Malik, Anselm Ting Su, Bonnie Bao Chee Tang, Florence Hui Sieng Tan, Norlela Sukor. Cardiac Autonomic Dysfunction in Obstructive Sleep Apnea: The Hidden Role of Vitamin D Deficiency. Journal of Evidence-Based Medicine, 2025, 18(3): e70071 DOI:10.1111/jebm.70071

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References

[1]

C. V. Senaratna, J. L. Perret, C. J. Lodge, et al., “Prevalence of Obstructive Sleep Apnea in the General Population: A Systematic Review,” Sleep Medicine Reviews 34 (2017): 70-81.

[2]

K. A. Franklin, C. Sahlin, H. Stenlund, and E. Lindberg, “Sleep Apnoea Is a Common Occurrence in Females,” European Respiratory Journal 41, no. 3 (2012): 610-615.

[3]

M. Yacoub, I. Youssef, M. O. Salifu, and S. I. McFarlane, “Cardiovascular Disease Risk in Obstructive Sleep Apnea: An Update,” Journal of Sleep Disorders and Therapy 7, no. 1 (2017): 283.

[4]

H. H. Loh and N. Sukor, “Obstructive Sleep Apnea and Vitamin D Level: Has the Dust Settled?,” Clinical Respiratory Journal 18, no. 3 (2023): e13593.

[5]

F. de la Guia-Galipienso, M. Martinez-Ferran, N. Vallecillo, C. J. Lavie, F. Sanchis-Gomar, and H. Pareja-Galeano, “Vitamin D and Cardiovascular Health,” Clinical Nutrition 40, no. 5 (2021): 2946-2957.

[6]

L. Y. Chen, X. H. Ye, J. L. Cheng, Y. Xue, D. Li, and J. Shao, “The Association Between Vitamin D Levels and Heart Rate Variability in Patients With Type 2 Diabetes Mellitus,” Medicine 101, no. 34 (2022): e30216.

[7]

M. C. Corretti, T. J. Anderson, E. J. Benjamin, et al., “Guidelines for the Ultrasound Assessment of Endothelial-dependent Flow-Mediated Vasodilation of the Brachial Artery: A Report of the International Brachial Artery Reactivity Task Force,” Journal of the American College of Cardiology 39, no. 2 (2002): 257-265.

[8]

T. Maruhashi, M. Kajikawa, S. Kishimoto, et al., “Diagnostic Criteria of Flow-Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin-Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery,” Journal of the American Heart Association 9, no. 2 (2020): e013915.

[9]

N. Cosentino, J. Campodonico, V. Milazzo, et al., “Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives,” Nutrients 13, no. 10 (2021): 3603.

[10]

D. X. Tishkoff, K. A. Nibbelink, K. H. Holmberg, L. Dandu, and R. U. Simpson, “Functional Vitamin D Receptor (VDR) in the T-Tubules of Cardiac Myocytes: VDR Knockout Cardiomyocyte Contractility,” Endocrinology 149, no. 2 (2008): 558-564.

[11]

M. Orini, S. van Duijvenboden, W. J. Young, et al., “Long-Term Association of Ultra-Short Heart Rate Variability With Cardiovascular Events,” Scientific Reports 13, no. 1 (2023): 18966.

[12]

M. N. Jarczok, K. Weimer, C. Braun, et al., “Heart Rate Variability in the Prediction of Mortality: A Systematic Review and Meta-Analysis of Healthy and Patient Populations,” Neuroscience and Biobehavioral Reviews 143 (2022): 104907.

[13]

D. S. Rata Mohan, S. Jawahir, A. Manual, et al., “Gender Differences in Health-Seeking Behaviour: Insights From the National Health and Morbidity Survey 2019,” BMC Health Services Research 25, no. 1 (2025): 900.

[14]

Y. Ng, A. J. A. Low, C. Chan, et al., “Healthcare Utilisation Patterns and Contributory Factors Among Middle-aged Adults: A Scoping Review,” Journal of Health, Population and Nutrition 43, no. 1 (2024): 218.

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2025 The Author(s). Journal of Evidence-Based Medicine published by Chinese Cochrane Center, West China Hospital of Sichuan University and John Wiley & Sons Australia, Ltd.

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