The ethics of some placebo-controlled randomized controlled trials

Elliot M. Levine; Carlos M. Fernandez

doi:10.1111/jebm.12625

Journal of Evidence-Based Medicine ›› 2024, Vol. 17 ›› Issue (2) : 267 -268. DOI: 10.1111/jebm.12625

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The ethics of some placebo-controlled randomized controlled trials

Elliot M. Levine ¹^,^†
, Carlos M. Fernandez ²

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Elliot M. Levine, Carlos M. Fernandez. The ethics of some placebo-controlled randomized controlled trials. Journal of Evidence-Based Medicine, 2024, 17(2): 267-268 DOI:10.1111/jebm.12625

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References

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[1]	Hafliðadóttir SH, Juhl CB, Nielsen SM, et al. Placebo response and effect in randomized clinical trials: meta-research with focus on contextual effects. Trials. 2021; 22(1), 493.

[2]	Giudice LC, As-Sanie S, Arjona Ferreira JC, et al. Once daily oral relugolix combination therapy versus placebo in patients with endometriosis-associated pain: two replicate phase 3 randomised, double-blind, studies (SPIRIT 1 and 2). Lancet. 2022; 388: 2267–2279.

[3]	Sieverding M, Gerlinger C, Seitz C. Substituting a randomized placebo control group with a historical placebo control group in an endometriosis pain trial: a case study re-evaluating trial data using historical control data from another file. BMJ Open. 2023; 13:e063188.

[4]	Varkey B. Principles of clinical ethics and their application to practice. Med Princ Pract. 2021; 30: 17–28.

[5]	Man F. The Rules of Logic Part 4: The laws of noncontradiction and transitive properties. Accessed January 19, 2024.

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2024 The Author(s). Journal of Evidence-Based Medicine published by Chinese Cochrane Center, West China Hospital of Sichuan University and John Wiley & Sons Australia, Ltd.