Nanofiber/Zwitterionic Hydrogel Composite for Anti-Foreign Body Reaction

Abstract

In this study, we developed a nanofiber/zwitterionic hydrogel composite aimed at overcoming the in vivo foreign body reaction. This composite leverages the adhesive properties of polydopamine(PDA)to integrate trimethylamine N-oxide(TMAO)zwitterionic hydrogel with a three-dimensional poly(lactic acid)(PLA)nanofiber membrane. The resulting material exhibits the robust mechanical properties characteristic of PLA, featuring a tensile strength of approximately 13 MPa and an elongation at break exceeding 20%. Furthermore, owing to the TMAO zwitterionic hydrogel, the composite demonstrates exceptional resistance to biological contamination. After 30 d in a murine model, the composite does not develop a dense collagen layer on its surface, maintaining a thickness of less than 30 μm.

Keywords

nanofiber / hydrogel / anti-foreign body reaction / zwitterion

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Funding

Fundamental Research Funds for the Central Universities, China(2232025A-09)