Nanofiber/Zwitterionic Hydrogel Composite for Anti-Foreign Body Reaction
Xiangyu DANG , Yujie GAO , Zhize CHEN
Journal of Donghua University(English Edition) ›› 2026, Vol. 43 ›› Issue (3) : 32 -43.
In this study, we developed a nanofiber/ zwitterionic hydrogel composite aimed at overcoming the in vivo foreign body reaction. This composite leverages the adhesive properties of polydopamine (PDA) to integrate trimethylamine N-oxide (TMAO) zwitterionic hydrogel with a three-dimensional poly(lactic acid) (PLA) nanofiber membrane. The resulting material exhibits the robust mechanical properties characteristic of PLA, featuring a tensile strength of approximately 13 MPa and an elongation at break exceeding 20%. Furthermore, owing to the TMAO zwitterionic hydrogel, the composite demonstrates exceptional resistance to biological contamination. After 30 d in a murine model, the composite does not develop a dense collagen layer on its surface, maintaining a thickness of less than 30 μm.
nanofiber / hydrogel / anti-foreign body reaction / zwitterion
Fundamental Research Funds for the Central Universities, China(2232025A-09)
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