Regulatory Role of Protein Ubiquitination in the Pathogenesis and Progression of Ulcerative Colitis

Ya Long Zhu; Chang Zheng Liu; Yue Li

doi:10.1111/1751-2980.70017

Journal of Digestive Diseases ›› 2025, Vol. 26 ›› Issue (9-10) :398 -405. DOI: 10.1111/1751-2980.70017

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Regulatory Role of Protein Ubiquitination in the Pathogenesis and Progression of Ulcerative Colitis

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Abstract

Ulcerative colitis (UC) is a multifactorial inflammatory bowel disease influenced by genetic susceptibility, environmental triggers, impaired intestinal epithelial barrier function, dysbiosis of gut microbiota, and immune dysregulation. Ubiquitination, a crucial post-translational modification, plays a significant role in the initiation and progression of UC. Gaining a deeper understanding of the molecular mechanisms underlying ubiquitination may help establish novel therapeutic strategies for UC. This review emphasizes the role of ubiquitination in regulating the intestinal epithelial barrier, nuclear factor (NF)-κB signaling, and immune responses, with the aim of providing new perspectives and potential directions for targeted therapies in UC.

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colitis / immune response / intestinal epithelial barrier / NF-kappa B / ubiquitination / ulcerative

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Ya Long Zhu, Chang Zheng Liu, Yue Li. Regulatory Role of Protein Ubiquitination in the Pathogenesis and Progression of Ulcerative Colitis. Journal of Digestive Diseases, 2025, 26(9-10): 398-405 DOI:10.1111/1751-2980.70017

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2025 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.